Mouillon Jean-Marie, Persson Bengt L
Department of Chemistry and Biomedical Sciences, Kalmar University, Kalmar, Sweden.
FEMS Yeast Res. 2006 Mar;6(2):171-6. doi: 10.1111/j.1567-1364.2006.00036.x.
The mechanism involved in the cellular phosphate response of Saccharomyces cerevisiae forms part of the PHO pathway, which upon expression allows a co-ordinated cellular response and adaptation to changes in availability of external phosphate. Although genetic studies and analyses of the S. cerevisiae genome have produced much information on the components of the PHO pathway, little is known about how cells sense the environmental phosphate level and the mechanistic regulation of phosphate acquisition. Recent studies emphasize different levels in phosphate sensing and signalling in response to external phosphate fluctuations. This review integrates all these findings into a model involving rapid and long-term effects of phosphate sensing and signalling in S. cerevisiae. The model describes in particular how yeast cells are able to adjust phosphate acquisition by integrating the status of the intracellular phosphate pools together with the extracellular phosphate concentration.
酿酒酵母细胞内磷酸盐应答所涉及的机制是PHO途径的一部分，该途径在表达时可实现细胞的协调应答以及对外部磷酸盐可用性变化的适应。尽管对酿酒酵母基因组的遗传学研究和分析已经产生了许多关于PHO途径组成部分的信息，但对于细胞如何感知环境磷酸盐水平以及磷酸盐摄取的机制调控却知之甚少。最近的研究强调了在响应外部磷酸盐波动时磷酸盐感知和信号传导的不同层面。本综述将所有这些发现整合到一个涉及酿酒酵母中磷酸盐感知和信号传导的快速和长期效应的模型中。该模型特别描述了酵母细胞如何通过整合细胞内磷酸盐库的状态和细胞外磷酸盐浓度来调节磷酸盐摄取。
