Fichi G, Flamini G, Zaralli L J, Perrucci S
Dipartimento di Patologia Animale, Profilassi ed Igiene degli Alimenti-Faculty of Veterinary Medicine of Pisa University, Italy.
Phytomedicine. 2007 Feb;14(2-3):227-31. doi: 10.1016/j.phymed.2006.01.004. Epub 2006 Feb 17.
The aim of the present study was to investigate the in vitro and in vivo acaricidal effects of an essential oil of Cinnamomum zeylanicun leaves on Psoroptes cuniculi, a mange mite. In vitro, 2.5 ml of the essential oil diluted at different concentrations, from 10% to 0.03%, in paraffin oil were added to Petri dishes containing all motile stages of P. cuniculi. Mites mortality observed in these dishes was compared with that observed in untreated and treated (AcaCerulen R) control plates. In vivo, one group of six P. cuniculi infected rabbits was topically treated two times at seven days interval with two ml of the essential oil at the concentration of 2.5% in paraffin oil and compared with untreated and treated (AcaCerulen R) control groups of six rabbits each. After 24 h of contact, all concentrations of essential oil between 0.10 and 10% showed a good in vitro acaricidal efficacy if compared with the untreated controls (p<0.01), but only the concentrations between 0.16 and 10% turned out as active as the drug. In vivo, the treatment with the essential oil cured all infested rabbits and no statistical differences were observed with the treated control group.
本研究的目的是调查锡兰肉桂叶精油对兔痒螨（一种疥螨）的体外和体内杀螨效果。在体外，将2.5毫升稀释至不同浓度（从10%到0.03%）的精油加入含有兔痒螨所有活动阶段的培养皿中。将这些培养皿中观察到的螨虫死亡率与未处理和处理过的（AcaCerulen R）对照培养皿中观察到的死亡率进行比较。在体内，一组六只感染兔痒螨的兔子每隔七天用2毫升浓度为2.5%的石蜡油精油进行两次局部治疗，并与未处理和处理过的（AcaCerulen R）对照组（每组六只兔子）进行比较。接触24小时后，与未处理的对照组相比，0.10%至10%的所有精油浓度均显示出良好的体外杀螨效果（p<0.01），但只有0.16%至10%的浓度与药物一样有效。在体内，用精油治疗治愈了所有受感染的兔子，与治疗对照组相比未观察到统计学差异。
