Fulton Debra L, Sundararajan Saravanan, Badis Gwenael, Hughes Timothy R, Wasserman Wyeth W, Roach Jared C, Sladek Rob
Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada.
Genome Biol. 2009;10(3):R29. doi: 10.1186/gb-2009-10-3-r29. Epub 2009 Mar 12.
Unravelling regulatory programs governed by transcription factors (TFs) is fundamental to understanding biological systems. TFCat is a catalog of mouse and human TFs based on a reliable core collection of annotations obtained by expert review of the scientific literature. The collection, including proven and homology-based candidate TFs, is annotated within a function-based taxonomy and DNA-binding proteins are organized within a classification system. All data and user-feedback mechanisms are available at the TFCat portal (http://www.tfcat.ca).
解析由转录因子（TFs）调控的程序是理解生物系统的基础。TFCat是一个基于对科学文献进行专家评审而获得的可靠注释核心集合的小鼠和人类转录因子目录。该集合包括经过验证的和基于同源性的候选转录因子，在基于功能的分类法中进行注释，并且DNA结合蛋白在一个分类系统中进行组织。所有数据和用户反馈机制都可在TFCat门户网站（http://www.tfcat.ca）上获取。
