呼吸道合胞病毒转化的大鼠脑微血管内皮细胞产生一种转化生长因子-β样生长因子。
Production of a transforming growth factor-beta-like growth factor by RSV-transformed rat cerebral microvascular endothelial cells.
作者信息
Mooradian D L, Diglio C A
机构信息
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis.
出版信息
Tumour Biol. 1991;12(3):171-83. doi: 10.1159/000217702.
This study describes the preliminary characterization of a Rous sarcoma virus (RSV)-transformed rat cerebral microvascular endothelial cell (RCE-T1)-derived growth factor with biological properties similar to transforming growth factor-beta (TGF-beta). A significant portion of this RCE-T1-derived TGF-beta-like growth factor was secreted in an active form and its secretion was elevated 2- to 3-fold in late passage cultures comprised of rapidly growing, less differentiated cells exhibiting reduced sensitivity to the growth-inhibitory effects of exogenous TGF-beta 1. These data suggest that the RCE-T1 cell line may be a useful system in which to study the role of autocrine TGF-beta production in normal and aberrant endothelial cell growth.
本研究描述了一种源自劳氏肉瘤病毒（RSV）转化的大鼠脑微血管内皮细胞（RCE-T1）的生长因子的初步特性，该生长因子具有与转化生长因子-β（TGF-β）相似的生物学特性。这种源自RCE-T1的TGF-β样生长因子的很大一部分以活性形式分泌，并且在由快速生长、分化程度较低的细胞组成的传代后期培养物中，其分泌量提高了2至3倍，这些细胞对外源TGF-β1的生长抑制作用敏感性降低。这些数据表明，RCE-T1细胞系可能是一个有用的系统，可用于研究自分泌TGF-β产生在正常和异常内皮细胞生长中的作用。
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