Le Goff Paul
Joint Bone Spine. 2006 May;73(3):239-42. doi: 10.1016/j.jbspin.2005.03.022. Epub 2005 Nov 9.
The presence of abnormalities in fibromyalgia muscle using current methodological approaches is well established. The more serious abnormalities are demonstrated by histologic studies particularly on electron microscopy: disorganisation of Z bands and abnormalities in the number and shape of mitochondria. Biochemical studies and P 31 magnetic resonance spectroscopy show inconstant abnormalities of ATP and phosphocreatine levels. Mitochondrial abnormalities reduced capillary circulation and thickened capillary endothelium may result in decreased availability of oxygen and impaired oxidative phosphorylation as well as ATP synthesis. These abnormalities do not seem to be the consequences of the much-discussed deconditioning of muscles although these consequences are not well known. Further studies of energy metabolism of the muscle during exercise are needed.
使用当前的方法学手段已充分证实纤维肌痛患者的肌肉存在异常。组织学研究，尤其是电子显微镜检查显示出更严重的异常：Z带紊乱以及线粒体数量和形态异常。生化研究和磷31磁共振波谱显示ATP和磷酸肌酸水平存在不恒定的异常。线粒体异常、毛细血管循环减少和毛细血管内皮增厚可能导致氧供应减少、氧化磷酸化受损以及ATP合成受损。尽管这些后果尚不明确，但这些异常似乎并非备受讨论的肌肉失健的后果。需要进一步研究运动期间肌肉的能量代谢。
