Bengtsson A, Henriksson K G
Department of Internal Medicine, University Hospital, Linköping, Sweden.
J Rheumatol Suppl. 1989 Nov;19:144-9.
In Sweden, several studies have been performed in patients with fibromyalgia to study muscle morphology, chemistry and physiology in order to understand the origin of the most prominent symptoms in fibromyalgia: muscle pain, muscle fatigue and muscle stiffness. These studies have shown changes indicating disturbed microcirculation, mitochondrial damage and a reduced content of high energy phosphates. Thus, there may be an energy deficiency state in the resting painful muscle in fibromyalgia. Pain analysis has supported the idea that there is a nociceptive origin of the pain. Our hypothesis is that any condition that could lead to constant muscle hypoxia, e.g., through establishment of abnormal motor patterns, might be a possible cause of fibromyalgic pain.
在瑞典，已经对纤维肌痛患者进行了多项研究，以研究肌肉形态、化学和生理学，从而了解纤维肌痛最突出症状的根源：肌肉疼痛、肌肉疲劳和肌肉僵硬。这些研究显示出一些变化，表明微循环紊乱、线粒体损伤以及高能磷酸盐含量降低。因此，纤维肌痛患者静息时疼痛的肌肉可能存在能量缺乏状态。疼痛分析支持了疼痛具有伤害性起源这一观点。我们的假设是，任何可能导致持续性肌肉缺氧的状况，例如通过建立异常运动模式，都可能是纤维肌痛性疼痛的一个可能原因。
