Frange Cristina, Hirotsu Camila, Hachul Helena, Araujo Paula, Tufik Sergio, Andersen Monica L
Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Napoleão de Barros, 925, Vila Clementino, 04024-002, São Paulo, SP, Brazil.
Curr Pain Headache Rep. 2014;18(8):434. doi: 10.1007/s11916-014-0434-3.
Sleep disorders are highly prevalent in patients with fibromyalgia (FM). Many of the daytime symptoms, such as chronic pain and fatigue, may be related to the non-restorative sleep patterns associated with the disease. Pain influences the sleep process and sleep disturbances decrease the pain threshold in a reciprocal framework. Thus, understanding the link between sleep and FM has become an important research topic in basic science. Therefore, in the current review we connect these topics and provide some insights into the cyclic relationship between sleep and pain, which has been addressed mainly in animal models. Additionally, we highlight the urgent need for sleep studies in FM animal models, which might improve the knowledge base and accelerate advances in this field.
睡眠障碍在纤维肌痛（FM）患者中极为普遍。许多日间症状，如慢性疼痛和疲劳，可能与该疾病相关的非恢复性睡眠模式有关。疼痛影响睡眠过程，而睡眠障碍在相互作用的机制中会降低疼痛阈值。因此，了解睡眠与纤维肌痛之间的联系已成为基础科学中的一个重要研究课题。所以，在当前的综述中，我们将这些主题联系起来，并对睡眠与疼痛之间的循环关系提供一些见解，这一关系主要在动物模型中得到研究。此外，我们强调在纤维肌痛动物模型中进行睡眠研究的迫切需求，这可能会改善该领域的知识基础并加速进展。
