Orrenius S, McConkey D J, Nicotera P
Department of Toxicology, Karolinska Institutet, Stockholm, Sweden.
Adv Exp Med Biol. 1991;283:419-25. doi: 10.1007/978-1-4684-5877-0_57.
An uncontrolled and sustained increase in cytosolic Ca2+ concentration has been implicated as an early event in the development of anoxic or toxic cell injury. More recently it has become clear that an elevation of cytosolic Ca2+ is also involved in programmed cell death in the immune system. Here, we review some of our recent studies and provide further evidence for the role of Ca2+ in cell killing.
胞质Ca2+浓度不受控制地持续升高被认为是缺氧或毒性细胞损伤发生过程中的早期事件。最近已经明确，胞质Ca2+升高也参与免疫系统中的程序性细胞死亡。在此，我们回顾一些我们最近的研究，并为Ca2+在细胞杀伤中的作用提供进一步的证据。
