真菌性角膜炎期间细菌合并感染的患病率及范围
Prevalence and spectrum of bacterial co-infection during fungal keratitis.
作者信息
Pate J C, Jones D B, Wilhelmus K R
机构信息
Department of Opthalmology and Visual Science, University of Kentucky College of Medicine, Lexington, KY, USA.
出版信息
Br J Ophthalmol. 2006 Mar;90(3):289-92. doi: 10.1136/bjo.2005.081869.
Abstract
AIMS
To estimate the propensity of keratomycosis for parallel or secondary bacterial infection and to explore affinities among fungal and bacterial co-isolates.
METHODS
A retrospective review of laboratory records over 24 years yielded 152 episodes of culture positive fungal keratitis. After collating 65 corneal specimens having bacterial co-isolates, polymicrobial co-infection was defined as detection of concordant bacteria on smear and culture or on two or more different media.
RESULTS
30 (20%) keratomycoses met laboratory criteria for polymicrobial infection. The risk of bacterial co-infection was 3.2 (95% confidence interval, 1.7 to 5.8) times greater with yeast keratitis than with filamentous fungal keratitis.
CONCLUSIONS
Bacterial co-infection occasionally complicates fungal keratitis, particularly candidiasis.
摘要
目的
评估角膜真菌病发生平行或继发性细菌感染的倾向，并探索真菌和细菌共分离株之间的关联。
方法
对24年的实验室记录进行回顾性分析，共获得152例培养阳性真菌性角膜炎病例。在整理出65份有细菌共分离株的角膜标本后，将多微生物混合感染定义为在涂片和培养中或在两种或更多不同培养基上检测到一致的细菌。
结果
30例（20%）角膜真菌病符合多微生物感染的实验室标准。酵母菌性角膜炎发生细菌混合感染的风险比丝状真菌性角膜炎高3.2倍（95%置信区间，1.7至5.8）。
结论
细菌混合感染偶尔会使真菌性角膜炎复杂化，尤其是念珠菌病。
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