Ottaviani G, Matturri L, Mingrone R, Lavezzi A M
Institute of Pathology, Lino Rossi Research Centre for the study and prevention of unexpected perinatal death and SIDS, University of Milan, Italy.
J Clin Pathol. 2006 May;59(5):497-500. doi: 10.1136/jcp.2005.032037. Epub 2006 Feb 17.
To report the case of five month old female baby with a history of episodes of gastro-oesophageal reflux and pneumonia. Her sudden death offered a unique insight into the possible role of delayed neuronal maturation and hypoplasia of the hypoglossal nucleus in representing a likely morphological substrate of sudden death.
Morphometric analysis was carried out with an Image-Pro Plus Image analyser (Media Cybernetics) on both sides of the brain stem.
Hypoplasia and neuronal immaturity of the hypoglossal nucleus were demonstrated, accompanied by hypoplasia of the arcuate nucleus.
Much attention should be paid to the possible role of the hypoglossal nucleus in determining a lethal outcome in infancy through impairment of deglutition and subsequent recurrent episodes of pneumonia, and as a necropsy finding.
报告一名5个月大患有胃食管反流和肺炎发作史的女婴病例。她的猝死为深入了解舌下神经核延迟神经元成熟和发育不全在猝死可能的形态学基础中所起的作用提供了独特视角。
使用Image-Pro Plus图像分析仪（Media Cybernetics公司）对脑干两侧进行形态计量分析。
证实舌下神经核发育不全和神经元不成熟，同时伴有弓状核发育不全。
应高度重视舌下神经核在通过吞咽功能受损及随后反复发生肺炎导致婴儿期致命结局方面可能发挥的作用，以及作为尸检发现的意义。
