N6-甲基腺嘌呤：一种用于DNA-蛋白质相互作用的表观遗传信号。
N6-methyl-adenine: an epigenetic signal for DNA-protein interactions.
作者信息
Wion Didier, Casadesús Josep
机构信息
INSERM U318, CHU Michallon, Université Joseph Fourier, 38043 Grenoble, France.
出版信息
Nat Rev Microbiol. 2006 Mar;4(3):183-92. doi: 10.1038/nrmicro1350.
Abstract
N(6)-methyl-adenine is found in the genomes of bacteria, archaea, protists and fungi. Most bacterial DNA adenine methyltransferases are part of restriction-modification systems. Certain groups of Proteobacteria also harbour solitary DNA adenine methyltransferases that provide signals for DNA-protein interactions. In gamma-proteobacteria, Dam methylation regulates chromosome replication, nucleoid segregation, DNA repair, transposition of insertion elements and transcription of specific genes. In Salmonella, Haemophilus, Yersinia and Vibrio species and in pathogenic Escherichia coli, Dam methylation is required for virulence. In alpha-proteobacteria, CcrM methylation regulates the cell cycle in Caulobacter, Rhizobium and Agrobacterium, and has a role in Brucella abortus infection.
摘要
N6-甲基腺嘌呤存在于细菌、古菌、原生生物和真菌的基因组中。大多数细菌DNA腺嘌呤甲基转移酶是限制修饰系统的一部分。某些变形菌属的菌群也含有单独的DNA腺嘌呤甲基转移酶，这些酶为DNA-蛋白质相互作用提供信号。在γ-变形菌中，Dam甲基化调节染色体复制、类核分离、DNA修复、插入元件的转座以及特定基因的转录。在沙门氏菌、嗜血杆菌、耶尔森氏菌和弧菌属物种以及致病性大肠杆菌中，Dam甲基化是毒力所必需的。在α-变形菌中，CcrM甲基化调节柄杆菌属、根瘤菌属和土壤杆菌属中的细胞周期，并在流产布鲁氏菌感染中起作用。
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