Parikh-Patel Arti, Mills Paul K, Jain Ratnali V
California Cancer Registry, Public Health Institute, Sacramento, CA 95815-4402, USA.
Cancer Causes Control. 2006 Apr;17(3):267-72. doi: 10.1007/s10552-005-0520-2.
Very little is known about cancer survival patterns among the growing South Asian community in the United States.
Breast cancer survival patterns were evaluated among South Asians using California Cancer Registry data from 1988 to 1998, and breast cancer survival among South Asians was compared to non-Hispanic Whites and other Asian subgroups. The analysis included all female, invasive, histologically confirmed breast cancer cases diagnosed from 1988 to 1998. The outcome of interest was death due to breast cancer. The Kaplan-Meier method was used to calculate 5- and 10-year survival probabilities.
South Asians were less likely to be diagnosed with early stage carcinomas relative to non-Hispanic Whites, Chinese and Japanese individuals. In unadjusted analyses, South Asians experienced poorer survival than non-Hispanic Whites at later survival times. The 5- and 10-year unadjusted survival probabilities for South Asians were 84% and 76%, respectively, compared to those for non-Hispanic Whites, which were 87% and 80%, respectively. There was no significant difference in survival between South Asians and non-Hispanic Whites after multivariate adjustment.
These data suggest the need for targeted efforts to improve early stage diagnosis among South Asian women. Further research into the factors that influence survival among South Asians is also needed.
在美国不断增长的南亚裔群体中，人们对癌症生存模式知之甚少。
利用1988年至1998年加利福尼亚癌症登记处的数据评估南亚裔人群的乳腺癌生存模式，并将南亚裔人群的乳腺癌生存率与非西班牙裔白人及其他亚裔亚组进行比较。分析纳入了1988年至1998年期间诊断的所有女性、浸润性、组织学确诊的乳腺癌病例。感兴趣的结局是因乳腺癌死亡。采用Kaplan-Meier方法计算5年和10年生存概率。
相对于非西班牙裔白人、华裔和日裔个体，南亚裔被诊断为早期癌症的可能性较小。在未经调整的分析中，南亚裔在后期生存时间的生存率低于非西班牙裔白人。南亚裔的5年和10年未经调整的生存概率分别为84%和76%，而非西班牙裔白人的这一概率分别为87%和80%。多变量调整后，南亚裔和非西班牙裔白人之间的生存率没有显著差异。
这些数据表明需要有针对性地努力改善南亚裔女性的早期诊断。还需要进一步研究影响南亚裔生存率的因素。
