Field Evelyn F, Whishaw Ian Q, Pellis Sergio M, Watson Neil V
University of Lethbridge, Lethbridge Alberta, Canada.
Dev Psychobiol. 2006 Mar;48(2):111-20. doi: 10.1002/dev.20121.
The frequency of playful attack and the style of playful defense, are modifiable by gonadal steroids and change after puberty in male and female rats. The present study examined the play behavior exhibited by testicular feminized mutation (tfm)-affected males, who are insensitive to androgens but can bind estrogens aromatized from androgens, to determine the relative contributions of androgens and estrogens to the age-related changes in play behavior. tfm males did not exhibit a decrease in playful attack with age and were more likely to maintain the use of complete rotations, a juvenile form of playful defense, into adulthood. tfm males did however, show age related changes in the use of partial rotations and upright postures, two other forms of playful defense, that were similar to normal males. These data suggest that the development of play fighting and defense in males is dependent on both androgen- and estrogen-receptor-mediated effects.
嬉戏性攻击的频率和嬉戏性防御的方式可被性腺类固醇改变，并且在雄性和雌性大鼠青春期后会发生变化。本研究考察了受睾丸雌性化突变（tfm）影响的雄性大鼠的玩耍行为，这些雄性大鼠对雄激素不敏感，但能够结合由雄激素芳香化而来的雌激素，以确定雄激素和雌激素对玩耍行为中与年龄相关变化的相对贡献。tfm雄性大鼠的嬉戏性攻击行为不会随着年龄增长而减少，并且更有可能将完整旋转（一种幼年形式的嬉戏性防御）的行为方式保持到成年期。然而，tfm雄性大鼠在使用部分旋转和直立姿势（另外两种嬉戏性防御形式）方面确实表现出与年龄相关的变化，这与正常雄性大鼠相似。这些数据表明，雄性大鼠玩耍打斗和防御行为的发展依赖于雄激素受体和雌激素受体介导的效应。
