Pasch Andreas, Frey Felix J
Nephrol Dial Transplant. 2006 May;21(5):1184-7. doi: 10.1093/ndt/gfl016. Epub 2006 Feb 20.
Coxsackie B viruses types 1-6 (CVB1-6) occur worldwide and cause a broad spectrum of diseases, including myocarditis and aseptic meningitis. Although renal damage due to CVB has been suspected since the 1950s, these agents are only rarely searched for in today's clinical nephrological practice. Nevertheless, CVB can infect mesangial cells. Furthermore, infections with these viruses lead to a histological picture resembling mesangioproliferative glomerulonephritis and IgA-nephropathy in mice. In the present article, we provide an overview of this largely neglected topic, and of the slowly and steadily increasing evidence suggesting a link between coxsackieviral infections and kidney diseases.
1-6型柯萨奇B病毒（CVB1-6）在全球范围内均有出现，可引发多种疾病，包括心肌炎和无菌性脑膜炎。尽管自20世纪50年代以来就有人怀疑CVB会导致肾损伤，但在当今临床肾脏病学实践中，对这些病原体的检测却很少见。然而，CVB可感染系膜细胞。此外，这些病毒感染会导致小鼠出现类似于系膜增生性肾小球肾炎和IgA肾病的组织学表现。在本文中，我们概述了这个在很大程度上被忽视的主题，以及越来越多的证据表明柯萨奇病毒感染与肾脏疾病之间存在联系。
