Sugimoto Kazuo, Ishikawa Nobuyasu, Terano Takashi, Kitukawa Yoshio, Kubosawa Hitoshi, Ito Shoichi, Hattori Takamichi
Department of Clinical Allergology, Chiba Aoba Municipal Hospital, Chiba 260-0852, Japan.
Dermatology. 2006;212 Suppl 1:26-34. doi: 10.1159/000089196.
Atopic dermatitis (AD) is frequently associated with intestinal and cervical lesions. Staphylococcus aureus produces many kinds of toxins, the bacterial superantigens. The detection rate of toxins was 80.1% from 196 S. aureus strains. Neurological examinations revealed abnormalities in 59 out of 81 AD patients. Cervical magnetic resonance imaging (MRI) was performed in 46 patients randomly and showed abnormal findings in 38 of these patients. In 23 patients who underwent MRI and duodenal biopsy, 3 were found to be normal neurologically and 2 patients showed normal duodenal tissue. However, 18 patients had abnormal findings both on neurological examination and in duodenal tissue. Serial duodenal biopsy tests were performed in 10 AD patients. In 5 patients, the findings of chronic duodenitis disappeared after the therapy with povidone-iodine. These data indicate that the therapy was effective not only for the skin lesions, but improved gastrointestinal tract lesions and cervical myelopathy, by eradicating bacterial superantigens.
特应性皮炎（AD）常与肠道和颈部病变相关。金黄色葡萄球菌可产生多种毒素，即细菌超抗原。从196株金黄色葡萄球菌菌株中检测到毒素的比率为80.1%。神经学检查显示81例AD患者中有59例存在异常。对46例患者随机进行了颈部磁共振成像（MRI）检查，其中38例显示有异常发现。在23例接受MRI检查和十二指肠活检的患者中，3例神经学检查正常，2例十二指肠组织正常。然而，18例患者神经学检查和十二指肠组织均有异常发现。对10例AD患者进行了系列十二指肠活检检查。5例患者经聚维酮碘治疗后，慢性十二指肠炎症消失。这些数据表明，该疗法不仅对皮肤病变有效，而且通过根除细菌超抗原改善了胃肠道病变和颈椎脊髓病。
