Kwon Jung Hyun, Song Joon Chang, Lee Sang Hun, Lee So Young, Yang Chul Woo, Kim Yong Soo, Bang Byung Kee
Division of Nephrology, Department of Internal Medicine, Kangnam St Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
Korean J Intern Med. 2005 Dec;20(4):330-4. doi: 10.3904/kjim.2005.20.4.330.
Gingival hyperplasia is a frequent complication in transplant patients who receive cyclosporine or calcium channel blockers. We studied an unusual case involving a renal transplant recipient with post-transplant non-Hodgkin's lymphoma that manifested as gingival hyperplasia. We initially consider that it was a side effect of cyclosporine and nifedipine. The lesion did not respond to dose reductions or the withdrawal of cyclosporine and nifedipine, and the gingival hyperplasia progressed in a localized fashion, becoming ulcerated and bleeding easily. Histological examination revealed the presence of malignant lymphoma.
牙龈增生是接受环孢素或钙通道阻滞剂治疗的移植患者常见的并发症。我们研究了一个不寻常的病例,该病例涉及一名肾移植受者,其移植后非霍奇金淋巴瘤表现为牙龈增生。我们最初认为这是环孢素和硝苯地平的副作用。病变对减少剂量或停用环孢素和硝苯地平无反应,牙龈增生以局部方式进展,变得溃疡且容易出血。组织学检查显示存在恶性淋巴瘤。