Morgan J D, Swarbrick M J, Edwards C M, Donnelly P K
Department of Surgery, Leicester General Hospital, UK.
Transpl Int. 1994;7 Suppl 1:S320-1. doi: 10.1111/j.1432-2277.1994.tb01380.x.
Nifedipine increases the frequency and severity of gingival hyperplasia associated with CyA therapy in renal transplant recipients and this effect appears to be independent of whole-blood CyA levels. De novo malignancies have been reported arising in areas of gingival hyperplasia, in a group already at high risk of malignancy. Patients receiving CyA and nifedipine should receive advice regarding the need for strict oral hygiene to control the initial development of gingival hyperplasia, with severe cases being promptly referred for gingivectomy and histological examination.
硝苯地平会增加肾移植受者接受环孢素（CyA）治疗时牙龈增生的频率和严重程度，并且这种影响似乎与全血中环孢素水平无关。已有报告称，在一组本身就处于高恶性肿瘤风险的人群中，牙龈增生部位出现了新发恶性肿瘤。接受环孢素和硝苯地平治疗的患者应得到关于严格口腔卫生必要性的建议，以控制牙龈增生的初始发展，严重病例应立即转诊进行牙龈切除术和组织学检查。
