Chiozzi Viola, Rossi Filippo
Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano via Mancinelli 7 20131 Milan Italy
Nanoscale Adv. 2020 Aug 3;2(11):5090-5105. doi: 10.1039/d0na00411a. eCollection 2020 Nov 11.
In recent decades a great deal of research has been dedicated to the development of core-shell nanoparticles (NPs). We decided to focus our attention on NPs with inorganic cores and organic shells and divide them by area of application such as electrical applications, drug delivery, biomedical applications, imaging, chemistry and catalysis. Organic shells, consisting in most cases of polymers (natural or synthetic), proteins or complex sugars, can improve the performance of inorganic NPs by enhancing their biocompatibility, acting as anchor sites for molecular linkages or protecting them from oxidation. Moreover, suitable design of the shell thickness can improve the chemical and thermal stability of NPs together with the possibility of tuning and controlling the release of molecules from the core. In the future new discoveries will guarantee improvement in the properties of NPs, synthesis, and applications of this class of nanomaterials that are constantly evolving.
近几十年来，大量研究致力于核壳纳米粒子（NPs）的开发。我们决定将注意力集中在具有无机核和有机壳的纳米粒子上，并根据其应用领域进行分类，如电气应用、药物递送、生物医学应用、成像、化学和催化。有机壳在大多数情况下由聚合物（天然或合成）、蛋白质或复合糖组成，可以通过增强其生物相容性、作为分子连接的锚定位点或保护它们免受氧化来提高无机纳米粒子的性能。此外，壳厚度的合适设计可以提高纳米粒子的化学和热稳定性，同时还可以调节和控制分子从核中的释放。未来，新的发现将确保这类不断发展的纳米材料在性能、合成及应用方面得到改进。
