Mohammadzadeh Ghorban, Zarghami Nosratollah
Hyperlipidemia Research Center, Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
Int J Endocrinol Metab. 2013 Winter;11(1):3-10. doi: 10.5812/ijem.6535. Epub 2012 Dec 21.
Leptin, a protein released from adipose tissue, could have significant role in pathogenesis of obesity and type 2 diabetes mellitus.
This study aimed to evaluate variations in serum leptin levels in non-obese subjects with type 2 diabetes mellitus (T2DM).
We studied forty-one patients with type 2 diabetes. Fasting lipid profile, Hemoglobin A1c (HbA1c), serum leptin, insulin, and glucose levels were measured by standard methods.
The serum leptin level in type 2 diabetic patients (19.32 ± 11.43 ng/mL) was significantly lower than that in non-diabetic subjects (32.16 ± 11.02 ng/mL). Serum leptin level was strongly and positively correlated with body mass index (BMI) (r = 0.658, P < 0.0001) and calculated body fat percentage (r = 0.431, P < 0.0001) in all the study subjects with a better corrlation in the control subjcts compared to control cases (r = 0.661 for BMI and r = 0.466 for body fat). On the other hand, leptin showed a positive and significant correlation with insulin and HOMA- β (homeostasis model assessment for β-cell function) in both groups. Furthermore, leptin related to homeostasis model assessment for insulin resistance (HOMA-IR) (r = 0.422, P = 0.006) was observed only in T2DM subjects. Leptin showed negative correlation with waist to hip ratio in diabetic (r = -0.407, P =0.008) and non-diabetic subjects (r = -0.318, P =0.049). In the regression model, BMI, HOMA-β, and gender were independent predictors of leptin in all subjects. However, in non-diabetic and diabetic subjects, β-cell function and insulin were independent predictors, respectively (P =0.01).
It is speculated that lower serum leptin levels in diabetic patients may be a consequence of male gender. Moreover, results suggest that serum leptin level in women is influenced differently than that in men.
瘦素是一种由脂肪组织释放的蛋白质，可能在肥胖症和2型糖尿病的发病机制中发挥重要作用。
本研究旨在评估2型糖尿病（T2DM）非肥胖患者血清瘦素水平的变化。
我们研究了41例2型糖尿病患者。采用标准方法测量空腹血脂、糖化血红蛋白（HbA1c）、血清瘦素、胰岛素和血糖水平。
2型糖尿病患者的血清瘦素水平（19.32±11.43 ng/mL）显著低于非糖尿病患者（32.16±11.02 ng/mL）。在所有研究对象中，血清瘦素水平与体重指数（BMI）（r = 0.658，P < 0.0001）和计算得出的体脂百分比（r = 0.431，P < 0.0001）呈强正相关，与对照组相比，在对照组中相关性更好（BMI的r = 0.661，体脂的r = 0.466）。另一方面，两组中瘦素与胰岛素和HOMA-β（β细胞功能的稳态模型评估）均呈正相关且具有显著性。此外，仅在T2DM患者中观察到瘦素与胰岛素抵抗的稳态模型评估（HOMA-IR）相关（r = 0.422，P = 0.006）。在糖尿病患者（r = -0.407，P = 0.008）和非糖尿病患者（r = -0.318，P = 0.049）中，瘦素与腰臀比呈负相关。在回归模型中，BMI、HOMA-β和性别是所有研究对象中瘦素的独立预测因素。然而，在非糖尿病和糖尿病患者中，β细胞功能和胰岛素分别是独立预测因素（P = 0.01）。
推测糖尿病患者血清瘦素水平较低可能是男性性别的结果。此外，结果表明女性血清瘦素水平受到的影响与男性不同。
