Matsushita Kunihiro, Tamakoshi Koji, Yatsuya Hiroshi, Wada Keiko, Otsuka Rei, Takefuji Seiko, Hotta Yo, Kondo Takahisa, Murohara Toyoaki, Toyoshima Hideaki
Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-8550, Japan.
Int J Cardiol. 2008 Mar 14;124(3):339-44. doi: 10.1016/j.ijcard.2007.02.015. Epub 2007 Apr 11.
Despite a close association of adiponectin with metabolic syndrome (MetS), its usefulness as an additional MetS factor has not been well investigated.
We studied 2327 apparently healthy Japanese male office workers aged 35 to 66 years old and investigated cross-sectionally whether categorization by serum adiponectin distinguished participants' levels of high-sensitivity C-reactive protein (CRP) beyond the conventional MetS.
In a linear regression analysis, adiponectin was associated with CRP independently of all MetS factors (beta=-0.192, P<0.001). Furthermore, a graded decrease in CRP level was observed with elevation of adiponectin in every stratum characterized by the presence or absence of each MetS component (trend P<0.05 in all strata except those of decreased high-density lipoprotein cholesterol or hyperglycemia). Similarly, geometric means of CRP levels (mg/l) decreased as adiponectin increased from the lowest to the highest tertile in all strata classified by the number of MetS components, though a P value did not reach statistical significance in those with 3 MetS components (the stratum of 0 MetS component: 0.41 [95% confidence interval, 0.34-0.49], 0.32 [0.28-0.37] and 0.26 [0.23-0.30], trend P<0.001; 1 component: 0.45 [0.39-0.52], 0.38 [0.34-0.43], and 0.32 [0.28-0.36], trend P<0.001; 2 components: 0.58 [0.50-0.67], 0.51 [0.44-0.60], and 0.46 [0.38-0.55], trend P=0.043; 3 components: 0.80 [0.66-0.96], 0.69 [0.55-0.87], and 0.58 [0.39-0.85], trend P=0.139).
Adiponectin evaluation provides additional inflammatory information on conventional MetS, supporting the potential of hypoadiponectinemia as an additional MetS component for identifying high-risk individuals for cardiovascular disease.
尽管脂联素与代谢综合征（MetS）密切相关，但其作为MetS附加因素的作用尚未得到充分研究。
我们对2327名年龄在35至66岁之间、表面健康的日本男性上班族进行了研究，并进行横断面调查，以确定血清脂联素分类是否能区分传统MetS之外的参与者的高敏C反应蛋白（CRP）水平。
在线性回归分析中，脂联素与CRP独立相关，不受所有MetS因素影响（β=-0.192，P<0.001）。此外，在以每种MetS成分的存在或不存在为特征的每个分层中，随着脂联素升高，观察到CRP水平呈分级下降（除高密度脂蛋白胆固醇降低或高血糖分层外，所有分层的趋势P<0.05）。同样，在按MetS成分数量分类的所有分层中，随着脂联素从最低三分位数增加到最高三分位数，CRP水平的几何均值（mg/l）下降，尽管在有3种MetS成分的人群中P值未达到统计学显著性（0种MetS成分的分层：0.41[95%置信区间，0.34 - 0.49]，0.32[0.28 - 0.37]和0.26[0.23 - 0.30]，趋势P<0.001；1种成分：0.45[0.39 - 0.52]，0.38[0.34 - 0.43]，和0.32[0.28 - 0.36]，趋势P<0.001；2种成分：0.58[0.50 - 0.67]，0.51[0.44 - 0.60]，和0.46[0.38 - 0.55]，趋势P = 0.043；3种成分：0.80[0.66 - 0.96]，0.69[0.55 - 0.87]，和0.58[0.39 - 0.85]，趋势P = 0.139）。
脂联素评估为传统MetS提供了额外的炎症信息，支持低脂联素血症作为MetS附加成分用于识别心血管疾病高危个体的潜力。
