异乳糖神经酰胺（iGb3）和神经酰胺三己糖苷（Gb3）的化学酶法合成
Chemoenzymatic syntheses of iGb3 and Gb3.
作者信息
Yao Qingjia, Song Jing, Xia Chengfeng, Zhang Wenpeng, Wang Peng George
机构信息
Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
出版信息
Org Lett. 2006 Mar 2;8(5):911-4. doi: 10.1021/ol053070p.
PMID:16494472
Abstract
Efficient chemoenzymatic syntheses of iGb3 and Gb3 have been developed. Isoglobotrihexose and globotrihexose were enzymatically synthesized by a three-enzyme system in both solid and solution phases. Then iGb3 and Gb3 were chemically synthesized by coupling of the corresponding trisaccharides with lipid.
摘要
已开发出高效的化学酶法合成异麦芽三糖（iGb3）和麦芽三糖（Gb3）的方法。异麦芽三糖和麦芽三糖通过一个三酶系统在固相和溶液相中酶促合成。然后，通过将相应的三糖与脂质偶联，化学合成了iGb3和Gb3。
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