iGb3和Gb3的α异头物可刺激自然杀伤T细胞产生细胞因子。
Alpha anomers of iGb3 and Gb3 stimulate cytokine production by natural killer T cells.
作者信息
Yin Ning, Long Xiangtian, Goff Randal D, Zhou Dapeng, Cantu Carlos, Mattner Jochen, Mezard Pierre Saint, Teyton Luc, Bendelac Albert, Savage Paul B
机构信息
Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA.
出版信息
ACS Chem Biol. 2009 Mar 20;4(3):199-208. doi: 10.1021/cb800277n.
Abstract
Natural killer T cells (NKT cells) respond to presentation of specific glycolipids with release of a variety of proinflammatory and immunomodulatory cytokines. The repertoire of glycolipid antigens for these cells includes alpha-glycosylceramides, alpha-glycosyldiacylglycerols, and the triglycosylceramide iGb3. Two features of iGb3 set it apart from these other antigens: (i) three sugars are required for stimulation and (ii) the glycosidic bond between ceramide and the proximal sugar is beta in iGb3, whereas it is alpha in other antigens. We have synthesized the alpha versions of iGb3 and Gb3 and demonstrate that they are effective antigens for NKT cells and that they do not require lysosomal processing to the monoglycosylceramides for stimulation. These triglycosylceramides constitute a new class of antigen that stimulates NKT cells comparably to monoglycosylceramides.
摘要
自然杀伤T细胞（NKT细胞）通过释放多种促炎和免疫调节细胞因子来响应特定糖脂的呈递。这些细胞的糖脂抗原库包括α-糖基神经酰胺、α-糖基二酰甘油和三糖基神经酰胺iGb3。iGb3的两个特征使其与其他这些抗原区分开来：（i）刺激需要三个糖，并且（ii）在iGb3中神经酰胺与近端糖之间的糖苷键是β型，而在其他抗原中是α型。我们已经合成了iGb3和Gb3的α版本，并证明它们是NKT细胞的有效抗原，并且它们不需要溶酶体加工成单糖基神经酰胺来进行刺激。这些三糖基神经酰胺构成了一类新的抗原，其刺激NKT细胞的效果与单糖基神经酰胺相当。
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