Pokhodzeĭ I V, Bulychev A G, Ses' T P, Leont'eva E A
Probl Tuberk. 1991(4):10-3.
The paper deals with the examination of the role of phagocytes--alveolar macrophages and neutrophils--and peripheral monocytes, in the pathogenesis of idiopathic fibrosing alveolitis (IFA). As the disease aggravates, activation of the absorbing capacity of monocyte-macrophagal cells corresponds to a sharp rise in the level of circulating immune complexes in the blood of IFA patients. Higher activities of elastase and collagenase are observed in the IFA patients' bronchial lavage fluid.
本文探讨了吞噬细胞(肺泡巨噬细胞和中性粒细胞)以及外周单核细胞在特发性肺纤维化(IFA)发病机制中的作用。随着病情加重,单核细胞 - 巨噬细胞的吞噬能力激活与IFA患者血液中循环免疫复合物水平的急剧升高相对应。在IFA患者的支气管灌洗液中观察到弹性蛋白酶和胶原酶的活性更高。