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[诊断性支气管肺泡灌洗术在评估特发性肺纤维化治疗效果中的应用]

[Diagnostic bronchoalveolar lavage in assessing the efficacy of the treatment of idiopathic fibrosing alveolitis].

作者信息

Gerasin V A, Zhuravlev A V, Novikova L N, Palamarchuk G F

出版信息

Ter Arkh. 1988;60(12):63-6.

PMID:3247657
Abstract

A study of the results of repeated diagnostic bronchoalveolar lavage in 27 patients with idiopathic fibrosing alveolitis (IFA) has shown that the investigation of cellular composition of the bronchoalveolar content (BAC) made it possible to specify IFA activity and its therapy-related change. Normalization or a decrease below 6% of the neutrophil content in BAC was typical of achieving low activity and remission of disease. A relatively high count of neutrophils in BAC (over 10%) during therapy was observed in preserved significant IFA activity resistant to drug therapy.

摘要

一项针对27例特发性肺纤维化(IFA)患者重复进行诊断性支气管肺泡灌洗结果的研究表明,对支气管肺泡灌洗液(BAC)细胞成分的检测有助于明确IFA的活动度及其与治疗相关的变化。BAC中中性粒细胞含量恢复正常或降至6%以下是疾病达到低活动度和缓解的典型表现。在治疗期间,若BAC中中性粒细胞计数相对较高(超过10%),则提示存在对药物治疗耐药的显著IFA活动度。

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