D'iakova M E, Titarenko O T, Esmedliaeva D S, El'kin A V, Alekseeva N P, Perova T L
Biomed Khim. 2007 Sep-Oct;53(5):585-92.
Functional activity of the bronchoalveolar lavage fluid (BALF) phagocytes was studied in 33 and 16 patients with fibro-cavernosis (FC) and infiltrative (I) pulmonary tuberculosis (PT), respectively. Complex examination of BALF, alveolar macrophages (AM) and neutrophils (N) sedimented from BALF revealed interrelationship between functional activity of the cells and the form of PT. Higher activities in BALF of neopterin and elastase mainly secreted by activated AM and N respectively, reflect a higher secretory activity of both types of cells in FC - PT. These patients are also characterized by more pronounced bactericide activity of Ns, which significantly correlates with adenosine deaminase (ADA) activity. It is suggested that changes in BALF of various biochemical parameters examined (neopterin, elastase, ADA and its isoenzymes, 2-deoxyADA) and bactericide activity of the sedimented cells represent are the consequences of differend sides of BALF phagocytes functioning. According to modem notions about the mechanisms of their regulation different intercellular relations are suggested in different form of PT.
分别对33例纤维空洞型（FC）肺结核（PT）患者和16例浸润型（I）肺结核患者的支气管肺泡灌洗液（BALF）吞噬细胞的功能活性进行了研究。对BALF、从BALF中沉降出的肺泡巨噬细胞（AM）和中性粒细胞（N）进行的综合检查揭示了细胞功能活性与PT类型之间的相互关系。分别主要由活化的AM和N分泌的BALF中蝶呤和弹性蛋白酶的活性较高，这反映了FC-PT中这两种类型细胞的分泌活性较高。这些患者还具有更明显的N杀菌活性，这与腺苷脱氨酶（ADA）活性显著相关。提示所检测的BALF各种生化参数（蝶呤、弹性蛋白酶、ADA及其同工酶、2-脱氧ADA）的变化以及沉降细胞的杀菌活性是BALF吞噬细胞不同功能方面的结果。根据关于其调节机制的现代观念，在不同类型的PT中提出了不同的细胞间关系。
