Shibuya S, Takase Y, Aoyagi H, Orii K, Sharma N, Tsujii H, Tsuji H, Iwasaki Y
Department of Surgery, University of Tsukuba, Ibaraki, Japan.
Radiat Med. 1991 Jan-Feb;9(1):35-40.
Proton beam radiation therapy using 250 MeV protons was carried out on two patients with early gastric cancer (T1, N0, M0). One patient was an 85-year-old man with early gastric cancer of type IIa + IIc. The other one was a 70 year old man with early gastric cancer of type IIc. In both cases histological examination of biopsy specimens showed differentiated adenocarcinoma; distant metastasis was not found by other examinations. Both patients were considered inoperable due to their poor cardiac and/or respiratory functions. Therefore, it was decided to treat them by definitive proton irradiation, delivering total doses of 86 Gy and 83 Gy, respectively. In both patients, skin erythema that did not require any special treatment was found in the irradiation field. Hematobiological examinations did not show any abnormality. Although endoscopic examination at two years after irradiation in the former case and at seven months in the latter case showed persistent gastric ulcer at the site of the cancerous lesions, cancer cells were not found histologically. Therefore, we concluded that proton irradiation therapy was useful for inoperable early gastric cancers.
对两名早期胃癌（T1，N0，M0）患者进行了使用250兆电子伏特质子的质子束放射治疗。一名患者是一名85岁男性，患有IIa + IIc型早期胃癌。另一名是一名70岁男性，患有IIc型早期胃癌。在这两个病例中，活检标本的组织学检查均显示为分化型腺癌；其他检查未发现远处转移。由于心脏和/或呼吸功能较差，两名患者均被认为无法进行手术。因此，决定对他们进行根治性质子照射治疗，分别给予总剂量86 Gy和83 Gy。两名患者在照射野均出现了无需特殊治疗的皮肤红斑。血液生物学检查未显示任何异常。尽管在前一例照射后两年和后一例照射后七个月的内镜检查显示癌灶部位存在持续性胃溃疡，但组织学检查未发现癌细胞。因此，我们得出结论，质子照射疗法对无法手术的早期胃癌有效。
