Sakai Yutaka, Yamaji Taiki, Tabata Shinji, Ogawa Shinsaku, Yamaguchi Keizo, Mineshita Masamichi, Mizoue Tetsuya, Kono Suminori
Department of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Diabetes Res Clin Pract. 2006 Jul;73(1):83-8. doi: 10.1016/j.diabres.2005.12.010. Epub 2006 Feb 21.
To investigate the relation of alcohol use and cigarette smoking to glucose tolerance status, we performed a cross-sectional study of 3038 male officials aged 46-59 years in the Self-Defense Forces. Glucose tolerance status was determined by a 75-g oral glucose tolerance test. A self-administered questionnaire was used to ascertain alcohol use, smoking habits, and other lifestyle characteristics. Statistical adjustment was made for parental history of diabetes, body mass index, and leisure-time physical activity. Alcohol use was positively associated with impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes mellitus each. The association was dose-dependent, with odds of each category of glucose intolerance increased even among those with moderate alcohol use. Cigarette smoking was not related to any categories of glucose intolerance. Alcohol use may confer increased risks not only of type 2 diabetes mellitus but also of preceding glucose intolerance status. Smoking does not seem to deteriorate glucose tolerance.
为研究饮酒和吸烟与糖耐量状态的关系，我们对自卫队中3038名年龄在46至59岁的男性官员进行了一项横断面研究。通过75克口服葡萄糖耐量试验确定糖耐量状态。采用自行填写的问卷来确定饮酒情况、吸烟习惯和其他生活方式特征。对糖尿病家族史、体重指数和休闲时间体力活动进行了统计调整。饮酒与空腹血糖受损、糖耐量受损和2型糖尿病均呈正相关。这种关联呈剂量依赖性，即使在中度饮酒者中，各类糖耐量异常的几率也会增加。吸烟与任何类型的糖耐量异常均无关联。饮酒不仅可能增加2型糖尿病的风险，还可能增加先前糖耐量异常状态的风险。吸烟似乎不会使糖耐量恶化。
