Hepburn M J, Kortepeter M G, Pittman P R, Boudreau E F, Mangiafico J A, Buck P A, Norris S L, Anderson E L
Division of Medicine, United States Army Medical Research Institute for Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA.
Vaccine. 2006 Apr 5;24(15):2843-9. doi: 10.1016/j.vaccine.2005.12.055. Epub 2006 Jan 18.
A retrospective review was conducted of yellow fever vaccination among laboratory workers receiving annual serologic assessment to determine the initial and long-term response after boosting. Patients were divided into three groups based on pre-vaccination serology: Group 1, 1:10; Group 2, 1:20-1:40 and Group 3, >1:40. The percent with > or = four-fold increase in titers after booster vaccination were: 78% (646/829, Group 1), 65% (79/121, Group 2) and 10% (8/79, Group 3) (p<0.0001). The median times to titer failure (<1:40) were 798 days (Group 1), 3340 days (Group 2) and 7709 days (Group 3) (p<0.0001). Pre-vaccination serology influenced the initial and long-term response to yellow fever booster vaccination.
对接受年度血清学评估的实验室工作人员的黄热病疫苗接种情况进行了回顾性研究，以确定加强免疫后的初始反应和长期反应。根据接种疫苗前的血清学情况将患者分为三组：第1组，1:10；第2组，1:20 - 1:40；第3组，>1:40。加强免疫接种后滴度升高≥四倍的百分比分别为：78%（646/829，第1组）、65%（79/121，第2组）和10%（8/79，第3组）（p<0.0001）。滴度降至<1:40的中位时间分别为798天（第1组）、3340天（第2组）和7709天（第3组）（p<0.0001）。接种疫苗前的血清学情况影响了黄热病加强免疫接种的初始反应和长期反应。
