Cui Longzhu, Tominaga Eiji, Neoh Hui-Min, Hiramatsu Keiichi
Department of Bacteriology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, Japan 113-8421.
Antimicrob Agents Chemother. 2006 Mar;50(3):1079-82. doi: 10.1128/AAC.50.3.1079-1082.2006.
We present here findings of a strong positive correlation between reduced daptomycin susceptibility and vancomycin resistance in vancomycin-intermediate Staphylococcus aureus (VISA). This correlation is related to cell wall thickening, suggesting that, similar to the case with vancomycin resistance in VISA, the physical barrier of a thickened cell wall may contribute to daptomycin resistance in S. aureus.
我们在此展示了万古霉素中度敏感金黄色葡萄球菌（VISA）中达托霉素敏感性降低与万古霉素耐药性之间存在强正相关的研究结果。这种相关性与细胞壁增厚有关，这表明，类似于VISA中万古霉素耐药性的情况，增厚的细胞壁的物理屏障可能导致金黄色葡萄球菌对达托霉素产生耐药性。
