与其他五种噻唑类化合物及其他三种药物相比，替唑尼特和硝唑尼特对厌氧菌的活性。
Activities of tizoxanide and nitazoxanide compared to those of five other thiazolides and three other agents against anaerobic species.
作者信息
Pankuch Glenn A, Appelbaum Peter C
机构信息
Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, Pennsylvania 17033, USA.
出版信息
Antimicrob Agents Chemother. 2006 Mar;50(3):1112-7. doi: 10.1128/AAC.50.3.1112-1117.2006.
Abstract
Agar dilution was used, and MICs of metronidazole, tizoxanide, nitazoxanide, denitrotizoxanide, RM 4803, RM 4807, RM 4809, RM 4819, amoxicillin-clavulanate, and clindamycin were measured against 412 anaerobes. Nitazoxanide, tizoxanide, RM 4807, and RM 4809 were active against all groups, except for gram-positive non-spore-forming rods with 50% minimum inhibitory concentrations (when the latter were excluded) of 1 to 2 microg/ml and 90% minimum inhibitory concentrations of 4 to 8 microg/ml, respectively. Metronidazole MICs were usually lower against all groups except clostridia.
摘要
采用琼脂稀释法，测定了甲硝唑、替唑尼特、硝唑尼特、去硝基替唑尼特、RM 4803、RM 4807、RM 4809、RM 4819、阿莫西林-克拉维酸和克林霉素对412株厌氧菌的最低抑菌浓度（MIC）。硝唑尼特、替唑尼特、RM 4807和RM 4809对所有菌组均有活性，除革兰氏阳性无芽孢杆菌外，其50%最低抑菌浓度（排除后者时）分别为1至2微克/毫升，90%最低抑菌浓度为4至8微克/毫升。除梭菌外，甲硝唑对所有菌组 的MIC通常较低。
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