Yu Haiyang, Yang Shangbin, Li Haotao, Wu Rongjie, Lai Biqin, Zheng Qiujian
Department of Orthopedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Neurospine. 2023 Mar;20(1):164-180. doi: 10.14245/ns.2245184.296. Epub 2023 Mar 31.
After spinal cord injury (SCI), endogenous neural stem cells are activated and migrate to the injury site where they differentiate into astrocytes, but they rarely differentiate into neurons. It is difficult for brain-derived information to be transmitted through the injury site after SCI because of the lack of neurons that can relay neural information through the injury site, and the functional recovery of adult mammals is difficult to achieve. The development of bioactive materials, tissue engineering, stem cell therapy, and physiotherapy has provided new strategies for the treatment of SCI and shown broad application prospects, such as promoting endogenous neurogenesis after SCI. In this review, we focus on novel approaches including tissue engineering, stem cell technology, and physiotherapy to promote endogenous neurogenesis and their therapeutic effects on SCI. Moreover, we explore the mechanisms and challenges of endogenous neurogenesis for the repair of SCI.
脊髓损伤（SCI）后，内源性神经干细胞被激活并迁移至损伤部位，在那里它们分化为星形胶质细胞，但很少分化为神经元。由于缺乏能够通过损伤部位传递神经信息的神经元，SCI后大脑传来的信息很难通过损伤部位传递，成年哺乳动物的功能恢复也难以实现。生物活性材料、组织工程、干细胞疗法和物理疗法的发展为SCI的治疗提供了新策略，并展现出广阔的应用前景，比如促进SCI后的内源性神经发生。在本综述中，我们重点关注包括组织工程、干细胞技术和物理疗法在内的促进内源性神经发生的新方法及其对SCI的治疗效果。此外，我们还探讨了内源性神经发生修复SCI的机制和挑战。
