Chen Honglei, Schernhammer Eva, Schwarzschild Michael A, Ascherio Alberto
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Am J Epidemiol. 2006 Apr 15;163(8):726-30. doi: 10.1093/aje/kwj096. Epub 2006 Feb 22.
The authors prospectively investigated whether working rotating night shifts was associated with the risk of Parkinson's disease among 84,794 female nurses who reported years of night shift work in 1988 (the US Nurses' Health Study). After 975,912 person-years of follow-up (1988-2000), 181 incident Parkinson's disease cases were documented. Compared with nurses who never worked rotating night shifts, those with 15 years or more of night shift work had a 50% lower risk of Parkinson's disease after adjustment for age and smoking (95% confidence interval: 0.26, 0.97; p(trend) = 0.01). Sleep duration was positively associated with Parkinson's disease risk: The relative risk was 1.84 (95% confidence interval: 0.99, 3.42) when comparing nurses who reported 9 or more hours of sleep per day with those who slept 6 hours or less (p(trend) = 0.005). These data suggest that working night shifts may be protective against Parkinson's disease or that low tolerance for night shift work is an early marker of Parkinson's disease. Conversely, habitual longer sleep duration may be an earlier marker of Parkinson's disease. Because of the novelty and the exploratory nature of these findings, confirmation is needed.
作者对84794名1988年报告有多年夜班工作经历的女性护士（美国护士健康研究）进行前瞻性调查，探究从事轮班制夜班工作是否与帕金森病风险相关。经过975912人年的随访（1988 - 2000年），记录了181例帕金森病新发病例。与从未从事轮班制夜班工作的护士相比，从事夜班工作15年及以上的护士在调整年龄和吸烟因素后，患帕金森病的风险降低了50%（95%置信区间：0.26，0.97；p趋势 = 0.01）。睡眠时间与帕金森病风险呈正相关：与每天睡眠6小时或更少的护士相比，报告每天睡眠9小时或更多的护士相对风险为1.84（95%置信区间：0.99，3.42）（p趋势 = 0.005）。这些数据表明，从事夜班工作可能对帕金森病有预防作用，或者对夜班工作耐受性低是帕金森病的早期标志。相反，习惯性较长睡眠时间可能是帕金森病的早期标志。由于这些发现的新颖性和探索性，需要进一步证实。
