Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
Am J Prev Med. 2014 Mar;46(3 Suppl 1):S26-33. doi: 10.1016/j.amepre.2013.10.033.
Studies of breast cancer in women and laboratory studies provide evidence that shift work involving circadian rhythm disruption is a probable human carcinogen. However, evidence linking shift work and other circadian disruption factors to prostate cancer risk is limited.
To examine associations of work schedule (i.e., rotating shift work, fixed night and fixed afternoon/evening shift work); sleep duration; and insomnia frequency with prostate cancer mortality.
The Cancer Prevention Study-II is a large prospective cohort study of U.S. adults. Work schedule, sleep duration, insomnia frequency, and other information was self-reported in 1982. Among 305,057 employed men, aged ≥29 years who were cancer free at baseline, there were 4974 prostate cancer deaths during follow-up through 2010. In 2013, multivariable-adjusted relative risks (RRs) and 95% CIs were computed using Cox proportional hazards regression.
Work schedule and insomnia frequency were not associated with risk of fatal prostate cancer. Short sleep duration was associated with higher risk of prostate cancer during the first 8 years of follow-up, compared to 7 hours/night, the RRs (95% CIs) for 3-5 and 6 hours/night were 1.64 (1.06, 2.54), and 1.28 (0.98, 1.67), respectively. There was no association between sleep duration and fatal prostate cancer during later follow-up.
These results do not support associations of work schedule or insomnia frequency with prostate cancer mortality. The association between short sleep duration and higher risk of fatal prostate cancer only during the first 8 years of follow-up suggests that short sleep duration could affect later stages of prostate carcinogenesis.
乳腺癌的女性研究和实验室研究为证据表明，涉及昼夜节律打乱的轮班工作可能是人类致癌物质。然而，将轮班工作和其他昼夜节律打乱因素与前列腺癌风险联系起来的证据有限。
检查工作时间表（即，轮班工作、固定夜班和固定下午/夜间班）；睡眠时间；以及失眠频率与前列腺癌死亡率之间的关联。
癌症预防研究 II 是一项针对美国成年人的大型前瞻性队列研究。工作时间表、睡眠时间、失眠频率和其他信息于 1982 年进行了自我报告。在 305057 名年龄≥29 岁、基线时无癌症的在职男性中，随访期间（截至 2010 年）有 4974 例前列腺癌死亡。2013 年，使用 Cox 比例风险回归计算多变量调整后的相对风险（RR）和 95%置信区间。
工作时间表和失眠频率与致命性前列腺癌的风险无关。与每晚 7 小时相比，短睡眠时间与随访前 8 年内前列腺癌风险较高相关，RR（95%CI）分别为 3-5 小时/晚和 6 小时/晚为 1.64（1.06，2.54）和 1.28（0.98，1.67）。在随后的随访中，睡眠时间与致命性前列腺癌之间没有关联。
这些结果不支持工作时间表或失眠频率与前列腺癌死亡率之间的关联。短睡眠时间与致命性前列腺癌风险较高仅在随访的前 8 年内相关，这表明短睡眠时间可能会影响前列腺癌发生的后期阶段。
