Parton Robert G, Hanzal-Bayer Michael, Hancock John F
Institute for Molecular Bioscience, University of Queensland, Queensland 4072, Australia.
J Cell Sci. 2006 Mar 1;119(Pt 5):787-96. doi: 10.1242/jcs.02853.
Caveolae are striking morphological features of the plasma membrane of mammalian cells. Caveolins, the major proteins of caveolae, play a crucial role in the formation of these invaginations of the plasma membrane; however, the precise mechanisms involved are only just starting to be unravelled. Recent studies suggest that caveolae are stable structures first generated in the Golgi complex. Their formation and exit from the Golgi complex is associated with caveolin oligomerisation, acquisition of detergent insolubility, and association with cholesterol. Modelling of caveolin-membrane interactions together with in vitro studies of caveolin peptides are providing new insights into how caveolin-lipid interactions could generate the unique architecture of the caveolar domain.
小窝是哺乳动物细胞质膜显著的形态学特征。小窝蛋白是小窝的主要蛋白质，在质膜这些内陷结构的形成中起关键作用；然而，其中涉及的精确机制才刚刚开始被揭示。最近的研究表明，小窝是首先在高尔基体复合物中产生的稳定结构。它们在高尔基体复合物中的形成和离开与小窝蛋白的寡聚化、获得去污剂不溶性以及与胆固醇的结合有关。小窝蛋白与膜相互作用的模型以及小窝蛋白肽的体外研究，正在为小窝蛋白与脂质的相互作用如何产生小窝结构域的独特结构提供新的见解。
