一种CpG寡核苷酸可以保护小鼠免受低气溶胶攻击剂量的鼻疽伯克霍尔德菌的侵害。
A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei.
作者信息
Waag David M, McCluskie Michael J, Zhang Ningli, Krieg Arthur M
机构信息
Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, MD 21702-5011, USA.
出版信息
Infect Immun. 2006 Mar;74(3):1944-8. doi: 10.1128/IAI.74.3.1944-1948.2006.
Abstract
Treatment with an oligodeoxynucleotide (ODN) containing CPG motifs (CpG ODN 7909) was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei. Protection was associated with enhanced levels of gamma interferon (IFN-gamma)-inducible protein 10, interleukin-12 (IL-12), IFN-gamma, and IL-6. Preexposure therapy with CpG ODNs may protect victims of a biological attack from glanders.
摘要
研究发现，用含胞嘧啶-磷酸-鸟嘌呤基序的寡脱氧核苷酸（ODN）（CpG ODN 7909）进行治疗，可保护BALB/c小鼠在经鼻疽伯克霍尔德菌气溶胶攻击后免受肺部感染或死亡。这种保护作用与γ干扰素（IFN-γ）诱导蛋白10、白细胞介素-12（IL-12）、IFN-γ和IL-6水平升高有关。用CpG ODN进行暴露前治疗可能会保护生物攻击的受害者免受鼻疽感染。
相似文献
1
A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei.一种CpG寡核苷酸可以保护小鼠免受低气溶胶攻击剂量的鼻疽伯克霍尔德菌的侵害。
Infect Immun. 2006 Mar;74(3):1944-8. doi: 10.1128/IAI.74.3.1944-1948.2006.
2
Interleukin-12 induces a Th1-like response to Burkholderia mallei and limited protection in BALB/c mice.白细胞介素-12诱导BALB/c小鼠对鼻疽伯克霍尔德菌产生类似Th1的反应及有限保护。
Vaccine. 2006 Feb 27;24(9):1413-20. doi: 10.1016/j.vaccine.2005.09.021. Epub 2005 Sep 22.
3
Immunostimulatory CpG oligodeoxynucleotide confers protection in a murine model of infection with Burkholderia pseudomallei.免疫刺激型CpG寡脱氧核苷酸在小鼠类鼻疽杆菌感染模型中具有保护作用。
Infect Immun. 2004 Aug;72(8):4494-502. doi: 10.1128/IAI.72.8.4494-4502.2004.
4
Aerogenic vaccination with a Burkholderia mallei auxotroph protects against aerosol-initiated glanders in mice.用鼻疽伯克霍尔德菌营养缺陷型菌株进行气溶胶接种可保护小鼠免受气溶胶引发的鼻疽感染。
Vaccine. 2005 Mar 14;23(16):1986-92. doi: 10.1016/j.vaccine.2004.10.017.
5
CpG-containing ODN has a limited role in the protection against Toxoplasma gondii.含CpG的寡脱氧核苷酸在抗弓形虫感染的保护作用中作用有限。
Parasite Immunol. 2004 Feb;26(2):67-73. doi: 10.1111/j.0141-9838.2004.00684.x.
6
Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders.热灭活的泰国伯克霍尔德菌、鼻疽伯克霍尔德菌或类鼻疽伯克霍尔德菌对实验性类鼻疽和鼻疽的保护效力。
Vaccine. 2009 Jul 16;27(33):4447-51. doi: 10.1016/j.vaccine.2009.05.040. Epub 2009 May 31.
7
CpG-ODN inhibits airway inflammation at effector phase through down-regulation of antigen-specific Th2-cell migration into lung.CpG寡脱氧核苷酸通过下调抗原特异性Th2细胞向肺内的迁移，在效应阶段抑制气道炎症。
Int Immunol. 2008 Feb;20(2):259-66. doi: 10.1093/intimm/dxm138. Epub 2007 Dec 21.
8
Monoclonal antibodies passively protect BALB/c mice against Burkholderia mallei aerosol challenge.单克隆抗体可被动保护BALB/c小鼠免受鼻疽伯克霍尔德菌气溶胶攻击。
Infect Immun. 2006 Mar;74(3):1958-61. doi: 10.1128/IAI.74.3.1958-1961.2006.
9
Use of a safe, reproducible, and rapid aerosol delivery method to study infection by Burkholderia pseudomallei and Burkholderia mallei in mice.使用一种安全、可重现且快速的气溶胶输送方法来研究小鼠感染类鼻疽伯克霍尔德菌和鼻疽伯克霍尔德菌。
PLoS One. 2013 Oct 2;8(10):e76804. doi: 10.1371/journal.pone.0076804. eCollection 2013.
10
[A study on the mechanisms of mycobacterial clearance induced by CpG-oligodeoxynucleotides in mice].[CpG-寡脱氧核苷酸诱导小鼠清除分枝杆菌的机制研究]
Zhonghua Jie He He Hu Xi Za Zhi. 2008 Jan;31(1):46-50.
引用本文的文献
1
Role of Trained Immunity in Heath and Disease.训练有素的免疫在健康与疾病中的作用。
Curr Cardiol Rep. 2025 Jan 13;27(1):18. doi: 10.1007/s11886-024-02167-7.
2
Single-stranded DNA oligonucleotides containing CpG motifs are non-stimulatory but offer protection against .含有 CpG 基序的单链 DNA 寡核苷酸无刺激作用，但能提供保护作用，防止 。
Front Cell Infect Microbiol. 2024 Oct 18;14:1458435. doi: 10.3389/fcimb.2024.1458435. eCollection 2024.
3
A novel gonorrhea vaccine composed of MetQ lipoprotein formulated with CpG shortens experimental murine infection.一种新型淋病疫苗，由 MetQ 脂蛋白与 CpG 短链组成，可缩短实验鼠感染时间。
Vaccine. 2020 Dec 3;38(51):8175-8184. doi: 10.1016/j.vaccine.2020.10.077. Epub 2020 Nov 5.
4
Multicomponent gold nano-glycoconjugate as a highly immunogenic and protective platform against .多组分金纳米糖缀合物作为一种针对……的高免疫原性和保护性平台
NPJ Vaccines. 2020 Sep 10;5:82. doi: 10.1038/s41541-020-00229-9. eCollection 2020.
5
Gene expression profiles identify both MyD88-independent and MyD88-dependent pathways involved in the maturation of dendritic cells mediated by heparan sulfate: a novel adjuvant.基因表达谱鉴定出硫酸乙酰肝素介导的树突状细胞成熟过程中涉及的MyD88非依赖和MyD88依赖途径：一种新型佐剂。
Hum Vaccin Immunother. 2014;10(12):3711-21. doi: 10.4161/21645515.2014.980682.
6
The impact of "omic" and imaging technologies on assessing the host immune response to biodefence agents.“组学”和成像技术对评估宿主免疫反应生物防御剂的影响。
J Immunol Res. 2014;2014:237043. doi: 10.1155/2014/237043. Epub 2014 Sep 16.
7
Protective response to subunit vaccination against intranasal and challenge.针对鼻内接种和攻毒的亚单位疫苗接种的保护性反应。
Procedia Vaccinol. 2010;2(1). doi: 10.1016/j.provac.2010.03.013.
8
Monitoring Therapeutic Treatments against Infections Using Imaging Techniques.使用成像技术监测针对感染的治疗
Pathogens. 2013 Jun 1;2(2):383-401. doi: 10.3390/pathogens2020383.
9
CRISPLD2 is expressed at low levels during septic shock and is associated with procalcitonin.CRISPLD2 在脓毒性休克期间低表达，并与降钙素原相关。
PLoS One. 2013 Jun 14;8(6):e65743. doi: 10.1371/journal.pone.0065743. Print 2013.
10
Intranasal prophylaxis with CpG oligodeoxynucleotide can protect against Yersinia pestis infection.鼻腔内用 CpG 寡脱氧核苷酸进行预防可以预防鼠疫耶尔森菌感染。
Infect Immun. 2013 Jun;81(6):2123-32. doi: 10.1128/IAI.00316-13. Epub 2013 Apr 1.
本文引用的文献
1
Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist.皮下注射而非静脉注射合成的B类CpG寡脱氧核苷酸TLR9激动剂CPG 7909后，正常志愿者体内可诱导出全身性TH1样固有免疫。
J Immunother. 2004 Nov-Dec;27(6):460-71. doi: 10.1097/00002371-200411000-00006.
2
Immunostimulatory CpG oligodeoxynucleotide confers protection in a murine model of infection with Burkholderia pseudomallei.免疫刺激型CpG寡脱氧核苷酸在小鼠类鼻疽杆菌感染模型中具有保护作用。
Infect Immun. 2004 Aug;72(8):4494-502. doi: 10.1128/IAI.72.8.4494-4502.2004.
3
Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities.具有不同免疫刺激活性的三类CpG寡脱氧核苷酸的特性分析。
Eur J Immunol. 2004 Jan;34(1):251-62. doi: 10.1002/eji.200324032.
4
CpG oligodeoxynucleotides protect normal and SIV-infected macaques from Leishmania infection.CpG寡脱氧核苷酸可保护正常和感染猴免疫缺陷病毒的猕猴免受利什曼原虫感染。
J Immunol. 2003 May 1;170(9):4717-23. doi: 10.4049/jimmunol.170.9.4717.
5
Impact of inhalation exposure modality and particle size on the respiratory deposition of ricin in BALB/c mice.吸入暴露方式和颗粒大小对蓖麻毒素在BALB/c小鼠呼吸道沉积的影响。
Inhal Toxicol. 2003 May;15(6):619-38. doi: 10.1080/08958370390205092.
6
CpG ODN enhances uptake of bacteria by mouse macrophages.CpG寡脱氧核苷酸增强小鼠巨噬细胞对细菌的摄取。
Clin Exp Immunol. 2003 Apr;132(1):70-5. doi: 10.1046/j.1365-2249.2003.02107.x.
7
CpG ODN activates NO and iNOS production in mouse macrophage cell line (RAW 264.7).CpG寡脱氧核苷酸激活小鼠巨噬细胞系（RAW 264.7）中一氧化氮和诱导型一氧化氮合酶的产生。
Clin Exp Immunol. 2002 Jun;128(3):467-73. doi: 10.1046/j.1365-2249.2002.01866.x.
8
Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides.人外周血单个核细胞亚群中Toll样受体1-10 mRNA的定量表达及对CpG寡脱氧核苷酸的敏感性
J Immunol. 2002 May 1;168(9):4531-7. doi: 10.4049/jimmunol.168.9.4531.
9
CpG motifs in bacterial DNA and their immune effects.细菌DNA中的CpG基序及其免疫效应。
Annu Rev Immunol. 2002;20:709-60. doi: 10.1146/annurev.immunol.20.100301.064842. Epub 2001 Oct 4.
10
Distinct CpG oligonucleotide sequences activate human gamma delta T cells via interferon-alpha/-beta.不同的CpG寡核苷酸序列通过α/β干扰素激活人γδ T细胞。
Eur J Immunol. 2001 Dec;31(12):3525-34. doi: 10.1002/1521-4141(200112)31:12<3525::aid-immu3525>3.0.co;2-5.
Zotero 插件