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伯氏疏螺旋体OspE旁系同源物与不同动物的补体因子H和血清蛋白的选择性结合：OspE在莱姆病发病机制中作用的可能扩展

Selective binding of Borrelia burgdorferi OspE paralogs to factor H and serum proteins from diverse animals: possible expansion of the role of OspE in Lyme disease pathogenesis.

作者信息

Hovis Kelley M, Tran Emily, Sundy Christina M, Buckles Eric, McDowell John V, Marconi Richard T

机构信息

Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, 1112 E. Clay St., Richmond, VA 23298-0678, USA.

出版信息

Infect Immun. 2006 Mar;74(3):1967-72. doi: 10.1128/IAI.74.3.1967-1972.2006.

DOI:10.1128/IAI.74.3.1967-1972.2006
PMID:16495576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1418677/
Abstract

The binding of Borrelia burgdorferi OspE, OspF, and family 163 (Elp) proteins to factor H/factor H-like protein 1 (FHL-1) and other serum proteins from different animals was assessed. OspE paralogs bound factor H and unidentified serum proteins from a subset of animals, while OspF and Elp proteins did not. These data advance our understanding of factor H binding, the host range of the Lyme spirochetes, and the expanding role of OspE in pathogenesis.

摘要

评估了伯氏疏螺旋体OspE、OspF和163家族（Elp）蛋白与不同动物的补体因子H/补体因子H样蛋白1（FHL-1）及其他血清蛋白的结合情况。OspE旁系同源物可结合补体因子H及部分动物的未鉴定血清蛋白，而OspF和Elp蛋白则不能。这些数据增进了我们对补体因子H结合、莱姆螺旋体宿主范围以及OspE在发病机制中不断扩大的作用的理解。

相似文献

1
Selective binding of Borrelia burgdorferi OspE paralogs to factor H and serum proteins from diverse animals: possible expansion of the role of OspE in Lyme disease pathogenesis.伯氏疏螺旋体OspE旁系同源物与不同动物的补体因子H和血清蛋白的选择性结合：OspE在莱姆病发病机制中作用的可能扩展
Infect Immun. 2006 Mar;74(3):1967-72. doi: 10.1128/IAI.74.3.1967-1972.2006.
2
Analysis of the OspE determinants involved in binding of factor H and OspE-targeting antibodies elicited during Borrelia burgdorferi infection in mice.对参与结合小鼠感染伯氏疏螺旋体过程中产生的补体因子H和靶向OspE抗体的OspE决定簇的分析。
Infect Immun. 2003 Jun;71(6):3587-96. doi: 10.1128/IAI.71.6.3587-3596.2003.
3
The OspE-related proteins inhibit complement deposition and enhance serum resistance of Borrelia burgdorferi, the lyme disease spirochete.OspE 相关蛋白抑制补体沉积并增强莱姆病螺旋体伯氏疏螺旋体的血清抗性。
Infect Immun. 2011 Apr;79(4):1451-7. doi: 10.1128/IAI.01274-10. Epub 2011 Jan 31.
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Functional characterization of BbCRASP-2, a distinct outer membrane protein of Borrelia burgdorferi that binds host complement regulators factor H and FHL-1.BbCRASP-2的功能特性，BbCRASP-2是伯氏疏螺旋体一种独特的外膜蛋白，可结合宿主补体调节因子H和FHL-1。
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Demonstration of the involvement of outer surface protein E coiled coil structural domains and higher order structural elements in the binding of infection-induced antibody and the complement-regulatory protein, factor H.证实外表面蛋白E卷曲螺旋结构域和高阶结构元件参与感染诱导抗体与补体调节蛋白H因子的结合。
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Sigma factor selectivity in Borrelia burgdorferi: RpoS recognition of the ospE/ospF/elp promoters is dependent on the sequence of the -10 region.伯氏疏螺旋体中的西格玛因子选择性：RpoS对ospE/ospF/elp启动子的识别取决于-10区域的序列。
Mol Microbiol. 2006 Mar;59(6):1859-75. doi: 10.1111/j.1365-2958.2006.05066.x.
7
Lysine-dependent multipoint binding of the Borrelia burgdorferi virulence factor outer surface protein E to the C terminus of factor H.伯氏疏螺旋体毒力因子外表面蛋白E与补体因子H C末端的赖氨酸依赖性多点结合
J Immunol. 2004 May 15;172(10):6195-201. doi: 10.4049/jimmunol.172.10.6195.
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Expression of complement factor H binding immunoevasion proteins in Borrelia garinii isolated from patients with neuroborreliosis.从神经莱姆病患者分离出的伽氏疏螺旋体中补体因子H结合免疫逃逸蛋白的表达
Eur J Immunol. 2005 Oct;35(10):3043-53. doi: 10.1002/eji.200526354.
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Complement inhibitor factor H binding to Lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs.补体抑制因子H与莱姆病螺旋体的结合是由多个质粒编码的外表面蛋白E旁系同源物的诱导表达介导的。
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OspE-related, OspF-related, and Elp lipoproteins are immunogenic in baboons experimentally infected with Borrelia burgdorferi and in human lyme disease patients.与OspE相关、与OspF相关的脂蛋白以及Elp脂蛋白，在实验感染伯氏疏螺旋体的狒狒和人类莱姆病患者中具有免疫原性。
J Clin Microbiol. 2002 Nov;40(11):4256-65. doi: 10.1128/JCM.40.11.4256-4265.2002.

引用本文的文献

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Borrelia surface proteins: new horizons in Lyme disease diagnosis.疏螺旋体表面蛋白：莱姆病诊断的新视野
Appl Microbiol Biotechnol. 2025 Jul 1;109(1):156. doi: 10.1007/s00253-025-13490-6.
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factor H-binding proteins are not required for serum resistance and infection in mammals.哺乳动物的血清抗性和感染并不需要H因子结合蛋白。
Infect Immun. 2024 Mar 12;92(3):e0052923. doi: 10.1128/iai.00529-23. Epub 2024 Jan 30.
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Erp and Rev Adhesins of the Lyme Disease Spirochete's Ubiquitous cp32 Prophages Assist the Bacterium during Vertebrate Infection.伯氏疏螺旋体普遍存在的 cp32 噬菌体的 Erp 和 Rev 黏附素在脊椎动物感染期间协助细菌。
Infect Immun. 2023 Mar 15;91(3):e0025022. doi: 10.1128/iai.00250-22. Epub 2023 Feb 28.
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Complement Evasion Contributes to Lyme Borreliae-Host Associations.补体逃逸促进莱姆螺旋体与宿主的关联。
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New Insights Into CRASP-Mediated Complement Evasion in the Lyme Disease Enzootic Cycle.新型洞察莱姆病地方流行循环中 CRASP 介导的补体逃避机制
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Further Insights Into the Interaction of Human and Animal Complement Regulator Factor H With Viable Lyme Disease Spirochetes.对人类和动物补体调节因子H与活的莱姆病螺旋体相互作用的进一步深入了解。
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Outer surface protein polymorphisms linked to host-spirochete association in Lyme borreliae.外表面蛋白多态性与莱姆螺旋体中的宿主-螺旋体关联有关。
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本文引用的文献

1
Evidence that the BBA68 protein (BbCRASP-1) of the Lyme disease spirochetes does not contribute to factor H-mediated immune evasion in humans and other animals.有证据表明，莱姆病螺旋体的BBA68蛋白（BbCRASP-1）对人类和其他动物中因子H介导的免疫逃逸没有作用。
Infect Immun. 2006 May;74(5):3030-4. doi: 10.1128/IAI.74.5.3030-3034.2006.
2
Demonstration of cotranscription and 1-methyl-3-nitroso-nitroguanidine induction of a 30-gene operon of Borrelia burgdorferi: evidence that the 32-kilobase circular plasmids are prophages.伯氏疏螺旋体30基因操纵子的共转录及1-甲基-3-亚硝基胍诱导的证明：32千碱基环状质粒是原噬菌体的证据
J Bacteriol. 2005 Dec;187(23):7985-95. doi: 10.1128/JB.187.23.7985-7995.2005.
3
Alternate sigma factor RpoS is required for the in vivo-specific repression of Borrelia burgdorferi plasmid lp54-borne ospA and lp6.6 genes.交替σ因子RpoS是疏螺旋体伯氏疏螺旋体质粒lp54携带的ospA和lp6.6基因体内特异性抑制所必需的。
J Bacteriol. 2005 Nov;187(22):7845-52. doi: 10.1128/JB.187.22.7845-7852.2005.
4
Demonstration of factor H-like protein 1 binding to Treponema denticola, a pathogen associated with periodontal disease in humans.证明类补体因子H1蛋白与齿垢密螺旋体结合，齿垢密螺旋体是一种与人类牙周疾病相关的病原体。
Infect Immun. 2005 Nov;73(11):7126-32. doi: 10.1128/IAI.73.11.7126-7132.2005.
5
Complement regulator-acquiring surface protein 1 imparts resistance to human serum in Borrelia burgdorferi.补体调节蛋白获取表面蛋白1赋予伯氏疏螺旋体对人血清的抗性。
J Immunol. 2005 Sep 1;175(5):3299-308. doi: 10.4049/jimmunol.175.5.3299.
6
Putative coiled-coil structural elements of the BBA68 protein of Lyme disease spirochetes are required for formation of its factor H binding site.莱姆病螺旋体的BBA68蛋白的假定卷曲螺旋结构元件是其因子H结合位点形成所必需的。
J Bacteriol. 2005 Feb;187(4):1317-23. doi: 10.1128/JB.187.4.1317-1323.2005.
7
bdrF2 of Lyme disease spirochetes is coexpressed with a series of cytoplasmic proteins and is produced specifically during early infection.莱姆病螺旋体的bdrF2与一系列细胞质蛋白共表达，且在感染早期特异性产生。
J Bacteriol. 2005 Jan;187(1):175-84. doi: 10.1128/JB.187.1.175-184.2005.
8
Demonstration of the involvement of outer surface protein E coiled coil structural domains and higher order structural elements in the binding of infection-induced antibody and the complement-regulatory protein, factor H.证实外表面蛋白E卷曲螺旋结构域和高阶结构元件参与感染诱导抗体与补体调节蛋白H因子的结合。
J Immunol. 2004 Dec 15;173(12):7471-80. doi: 10.4049/jimmunol.173.12.7471.
9
RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants.RpoS对伯氏疏螺旋体的一般应激反应并非至关重要，但它确实控制着一种或多种关键毒力决定因素的表达。
Infect Immun. 2004 Nov;72(11):6433-45. doi: 10.1128/IAI.72.11.6433-6445.2004.
10
Analysis of promoter elements involved in the transcriptional initiation of RpoS-dependent Borrelia burgdorferi genes.参与RpoS依赖性伯氏疏螺旋体基因转录起始的启动子元件分析。
J Bacteriol. 2004 Nov;186(21):7390-402. doi: 10.1128/JB.186.21.7390-7402.2004.