伯氏疏螺旋体OspE旁系同源物与不同动物的补体因子H和血清蛋白的选择性结合：OspE在莱姆病发病机制中作用的可能扩展
Selective binding of Borrelia burgdorferi OspE paralogs to factor H and serum proteins from diverse animals: possible expansion of the role of OspE in Lyme disease pathogenesis.
作者信息
Hovis Kelley M, Tran Emily, Sundy Christina M, Buckles Eric, McDowell John V, Marconi Richard T
机构信息
Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, 1112 E. Clay St., Richmond, VA 23298-0678, USA.
出版信息
Infect Immun. 2006 Mar;74(3):1967-72. doi: 10.1128/IAI.74.3.1967-1972.2006.
Abstract
The binding of Borrelia burgdorferi OspE, OspF, and family 163 (Elp) proteins to factor H/factor H-like protein 1 (FHL-1) and other serum proteins from different animals was assessed. OspE paralogs bound factor H and unidentified serum proteins from a subset of animals, while OspF and Elp proteins did not. These data advance our understanding of factor H binding, the host range of the Lyme spirochetes, and the expanding role of OspE in pathogenesis.
摘要
评估了伯氏疏螺旋体OspE、OspF和163家族（Elp）蛋白与不同动物的补体因子H/补体因子H样蛋白1（FHL-1）及其他血清蛋白的结合情况。OspE旁系同源物可结合补体因子H及部分动物的未鉴定血清蛋白，而OspF和Elp蛋白则不能。这些数据增进了我们对补体因子H结合、莱姆螺旋体宿主范围以及OspE在发病机制中不断扩大的作用的理解。
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