Ishimi Yoshiko, Sugiyama Fumie, Ezaki Junko, Fujioka Maiko, Wu Jian
Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan.
Biosci Biotechnol Biochem. 2006 Feb;70(2):363-8. doi: 10.1271/bbb.70.363.
The safety and effectiveness were examined of the spirulina alga on bone metabolism in ovariectomized estrogen-deficient rats and hindlimb-unloaded mice. The dosage range was from an amount equal to that recommended in so-called health foods for humans (0.08 g/kg BW/day) to a 100-fold higher dose. The bone mineral density (BMD) of the whole femur and tibia of ovariectomized rats in the any spirulina-treated groups was not significantly different from that of the ovariectomized group, although BMD of the distal femur and proximal tibia was significantly lower in the spirulina-treated groups than in the ovariectomized group after a 6 week-experimental period. BMD of the femur and tibia was not affected by treatment with any dose of spirulina in hindlimb-unloaded mice. These results suggest that the intake of spirulina decreased BMD in the trabecular bone of rodents under estrogen-deficient conditions.
研究了螺旋藻对去卵巢雌激素缺乏大鼠和后肢去负荷小鼠骨代谢的安全性和有效性。剂量范围从相当于所谓人类健康食品中推荐的量（0.08 g/kg体重/天）到高100倍的剂量。在任何螺旋藻处理组中，去卵巢大鼠的整个股骨和胫骨的骨矿物质密度（BMD）与去卵巢组相比无显著差异，尽管在6周实验期后，螺旋藻处理组的股骨远端和胫骨近端的BMD显著低于去卵巢组。后肢去负荷小鼠的股骨和胫骨的BMD不受任何剂量螺旋藻处理的影响。这些结果表明，在雌激素缺乏的条件下，摄入螺旋藻会降低啮齿动物小梁骨的BMD。
