Kuvin Jeffrey T, Alsheikh-Ali Alawi A, Karas Richard H
Division of Cardiology, Department of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine Boston, Massachusettes 0211, USA.
J Cardiovasc Pharmacol. 2006 Feb;47(2):196-204. doi: 10.1097/01.fjc.0000199684.20578.7c.
There is a distinct inverse relationship between high-density lipoprotein cholesterol (HDL-C) and cardiovascular disease risk. HDL-C mediates cholesterol efflux from the vasculature and promotes anti-oxidant, anti-inflammatory, and anti-thrombotic effects. There are multiple lifestyle and therapeutic interventions that raise HDL-C, and there is increasing evidence that these interventions improve cardiovascular outcomes. Recent findings regarding the role of HDL-C in cholesterol metabolism offer new strategies designed to target atherosclerosis. This review highlights the utility of existing HDL-C-raising strategies and examines new potential therapies.
高密度脂蛋白胆固醇（HDL-C）与心血管疾病风险之间存在明显的负相关关系。HDL-C介导血管系统中的胆固醇流出，并促进抗氧化、抗炎和抗血栓形成作用。有多种生活方式和治疗干预措施可提高HDL-C，并且越来越多的证据表明这些干预措施可改善心血管结局。最近关于HDL-C在胆固醇代谢中作用的研究结果提供了旨在针对动脉粥样硬化的新策略。本综述强调了现有提高HDL-C策略的实用性，并探讨了新的潜在治疗方法。
