Chou Yuh-Yu, How Su-Wen, Huang Ching-How
Department of Pathology and Laboratory Medicine, Shin Kong Wu Ho-Su Memorial Hospital, and Taipei Medical University, Taiwan.
J Formos Med Assoc. 2005 Nov;104(11):843-7.
Follicular dendritic cell (FDC) sarcomas are extremely rare, with only 2 reported cases involving the palate. These tumors have typical oval to spindle cells with fine chromatin, obvious nucleoli and indistinct cell borders. They are usually arranged as sheets, whorls, or in a storiform pattern. Although FDC sarcoma has a characteristic morphologic picture, due to its rarity it may be mistaken for other types of sarcoma, carcinoma or melanoma. Immunohistochemical and ultrastructural studies are useful for confirmation of the diagnosis. We report a case of FDC sarcoma developing in the soft palate. The patient suffered from an oral cavity mass with dysphagia in the previous 2 months as well as body weight loss of 8 kg during the previous 6 months. He was well previously and denied any other systemic problems. Wide excision of the tumor was performed and no recurrence or metastasis was noted for 5 years. The success of the procedure may have been due to a well-defined tumor margin and less aggressive histological features. The ability to recognize and differentiate extranodal FDC tumors based on knowledge of their full morphologic spectrum is important as they have an intermediate malignant potential.
滤泡性树突状细胞（FDC）肉瘤极为罕见，仅有2例累及腭部的报道。这些肿瘤具有典型的椭圆形至梭形细胞，染色质细腻，核仁明显，细胞边界不清。它们通常呈片状、漩涡状或席纹状排列。尽管FDC肉瘤有特征性的形态学表现，但由于其罕见性，可能会被误诊为其他类型的肉瘤、癌或黑色素瘤。免疫组织化学和超微结构研究有助于确诊。我们报告1例发生于软腭的FDC肉瘤。患者在过去2个月出现口腔肿物伴吞咽困难，在过去6个月体重减轻8 kg。他既往身体健康，否认有任何其他全身性问题。对肿瘤进行了广泛切除，5年未见复发或转移。手术成功可能归因于肿瘤边界清晰以及组织学特征侵袭性较小。基于对其完整形态学谱的了解来识别和区分结外FDC肿瘤的能力很重要，因为它们具有中等恶性潜能。
