Engelberg I, Kohn J
Department of Chemistry, Rutgers, State University of New Jersey, New Brunswick.
Biomaterials. 1991 Apr;12(3):292-304. doi: 10.1016/0142-9612(91)90037-b.
The physico-mechanical properties of degradable polymers used for medical applications have been characterized. The following polymers were included in this study: three samples of poly(ortho esters) derived from 3,9-bis(ethylidene 2,4,8,10-tetraoxaspiro[5,5]undecane) and various ratios of 1,6-hexanediol and trans-cyclohexane dimethanol, poly(glycolic acid), six samples of poly(L-lactic acid) and poly(D,L-lactic acid) with mol wt from 21,000 to 550,000, poly(epsilon-caprolactone), poly(beta-hydroxybutyrate) and three copolymers of beta-hydroxybutyric acid and various amounts of hydroxyvaleric acid, one sample each of two different types of poly(anhydrides), poly(trimethylene carbonate) and two different poly(imino-carbonates). For each polymer, the thermal properties (glass transition temperature, crystallization, melting and decomposition points) were determined by differential scanning calorimetry and by thermogravimetric analysis. The tensile properties (Young's modulus, tensile strength and elongation at yield and break) were determined by tensile testing on an Instron stress-strain tester. The flexural storage modulus as a function of temperature was determined by dynamic mechanical analysis.
已对用于医疗应用的可降解聚合物的物理机械性能进行了表征。本研究包括以下聚合物：三种由3,9-双（亚乙基-2,4,8,10-四氧杂螺[5,5]十一烷）与不同比例的1,6-己二醇和反式环己烷二甲醇衍生而来的聚原酸酯样品、聚乙醇酸、六种分子量在21,000至550,000之间的聚（L-乳酸）和聚（D,L-乳酸）样品、聚己内酯、聚β-羟基丁酸以及三种β-羟基丁酸与不同量羟基戊酸的共聚物、两种不同类型聚酸酐的各一个样品、聚三亚甲基碳酸酯以及两种不同的聚亚氨基碳酸酯。对于每种聚合物，通过差示扫描量热法和热重分析测定其热性能（玻璃化转变温度、结晶温度、熔点和分解温度）。通过在英斯特朗应力应变测试仪上进行拉伸试验测定拉伸性能（杨氏模量、拉伸强度以及屈服和断裂伸长率）。通过动态力学分析测定作为温度函数的弯曲储能模量。
