通过连续交叉复分解-内酯化反应合成γ,δ-不饱和-β-酮内酯：通往大环内酯类抗生素(-)-A26771B的简便途径。
Synthesis of gamma,delta-unsaturated-beta-keto lactones via sequential cross metathesis-lactonization: a facile entry to macrolide antibiotic (-)-A26771B.
作者信息
Gebauer Julian, Blechert Siegfried
机构信息
Institut für Chemie, Technische Universität Berlin, Strasse des 17, Juni 135, D-10623 Berlin, Germany.
出版信息
J Org Chem. 2006 Mar 3;71(5):2021-5. doi: 10.1021/jo052421a.
PMID:16496989
Abstract
A simple access to gamma,delta-unsaturated-beta-keto lactones is presented, allowing a rapid total synthesis of the naturally occurring 16-membered macrolide antibiotic (-)-A26771B via cross metathesis, asymmetric dihydroxylation, and lactonization as the key steps.
摘要
本文介绍了一种简单合成γ,δ-不饱和-β-酮内酯的方法，该方法以交叉复分解反应、不对称双羟基化反应和内酯化反应为关键步骤，能够快速全合成天然存在的16元大环内酯抗生素(-)-A26771B。
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