An efficient synthesis of enantiomerically enriched trifluoromethylated 1,2-diols and 1,2-amino alcohols with quaternary stereocenters by diastereoselective addition of TMSCF3 to chiral 2-acyl-1,3-perhydrobenzoxazines.
作者信息
Pedrosa Rafael, Sayalero Sonia, Vicente Martina, Maestro Alicia
机构信息
Departamento de Química Organica, Facultad de Ciencias, Universidad de Valladolid, Dr. Mergelina s/n, 47011-Valladolid, Spain.
出版信息
J Org Chem. 2006 Mar 3;71(5):2177-80. doi: 10.1021/jo052458v.
PMID:16497014
Abstract
TMSCF3 adds to chiral 2-acyl-1,3-perhydrobenzoxazines with total diastereoselectivity leading to quaternary trifluoromethyl alcohols. Further transformation of the addition products yields enantiomerically enriched trifluoromethylated 1,2-diols and 1,2-amino alcohols.
摘要
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