Department of Chemistry, South University of Science and Technology of China , Shenzhen, 518055, P. R. China.
Org Lett. 2014 Jan 17;16(2):504-7. doi: 10.1021/ol403391v. Epub 2013 Dec 18.
The first example of a metal-free direct carbotrifluoromethylation of alkenes using inexpensive TMSCF3 as the CF3 source is described. The methodology not only exhibits high chemoselectivity for this transformation but also expands the substrate scope that is difficult to access by known transition-metal-catalyzed methods.
本文首次描述了一种使用廉价的 TMSCF3 作为 CF3 源的无金属直接烯丙基三氟甲基化反应的例子。该方法不仅对这种转化具有高化学选择性，而且还扩展了已知过渡金属催化方法难以获得的底物范围。
