Hampson Michelle, Tokoglu Fuyuze, Sun Zhongdong, Schafer Robin J, Skudlarski Pawel, Gore John C, Constable R Todd
Department of Diagnostic Radiology, Yale School of Medicine, P.O. Box 208042, TAC, New Haven, CT 06520-8042, USA.
Neuroimage. 2006 Jun;31(2):513-9. doi: 10.1016/j.neuroimage.2005.12.040. Epub 2006 Feb 23.
Correlations between temporal fluctuations in MRI signals may reveal functional connectivity between brain regions within individual subjects. Such correlations would be especially useful indices of functional connectivity if they covary with behavioral performance or other subject variables. This study investigated whether such a relationship could be demonstrated in the context of the reading circuit in the brain. The method proved sufficiently powerful to reveal significant correlations between the reading abilities of subjects and the strength of their functional connection between left Brodmann's area 39 and Broca's area during reading. This suggests that the disconnection of the angular gyrus previously reported for dyslexic readers is part of a larger continuum in which poor (but nonimpaired readers) also show reduced connectivity to the region. In addition, it illustrates the potential power of paradigms that examine correlations between behavior and functional brain connections.
磁共振成像（MRI）信号的时间波动之间的相关性可能揭示个体受试者大脑区域之间的功能连接。如果这些相关性与行为表现或其他受试者变量共变，那么它们将是功能连接的特别有用的指标。本研究调查了在大脑阅读回路的背景下是否能证明这种关系。该方法被证明具有足够的强大功能，能够揭示受试者的阅读能力与他们在阅读过程中左布罗德曼区39和布洛卡区之间功能连接强度之间的显著相关性。这表明，先前报道的阅读障碍读者角回的断开连接是一个更大连续体的一部分，在这个连续体中，阅读能力差（但未受损）的读者也表现出与该区域的连接减少。此外，它还说明了研究行为与功能性脑连接之间相关性的范式的潜在力量。
