Liang Ai-hua, Xu Yan-ju, Shang Min-feng
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing.
Zhongguo Zhong Yao Za Zhi. 2005 Dec;30(23):1809-11.
This article made a brief analysis of clinical adverse effects of cinnabar. Except for allergic reaction, almost all the adverse events of cinnabar were caused by unreasonable application. The majority of the poisoning cases were associated with excessive and/or long-term dosage, and improper preparation methods, such as decocting, heating or fumigating. Children showed to be prone to poisoning. The poisoning caused by unreasonable use of cinnabar should be considered to be drug alert, but not advert effect. And the toxicity of cinnabar could be avoided by normalizing the preparation method, controlling the dosage and duration.
本文对朱砂的临床不良反应进行了简要分析。除过敏反应外，朱砂几乎所有不良事件均由不合理应用所致。多数中毒病例与过量和/或长期用药以及不当的炮制方法有关，如煎煮、加热或熏蒸。儿童显示出易中毒倾向。不合理使用朱砂所致中毒应被视为药物警戒，而非药物不良反应。通过规范炮制方法、控制剂量和用药时间，朱砂的毒性是可以避免的。
