Zhong Wen-yuan, Hu Zhi-xing, Chen Shun-fang, Ji Shu-yu, Zhou Yi-ping, Li Ma-lin
Kunming Teachers College, Kunming 650031, China.
Yao Xue Xue Bao. 2005 Nov;40(11):997-1000.
To study the biochemistry of lanthanides, the cooperative action of inorganic and organic anti-tumor drugs.
A series of rare earth complexes were synthesized with Ln(NO3) 6H2O, Phen and 5-Fu. Their anti-tumor activity was measured by the improved MTT, SRB methods.
The formula of complex Ln(Phen)2(5-Fu)3(NO3)2(Ln = Y, La, Ce, Sm, Gd, Dy, Er; Phen = 1, 10-phenanthroline; 5-Fu = fluorouracil) was characterized by elemental analyses, molar conductivity, IR, TGA, and 13C NMR spectra. The preliminary biological activity studies indicated that Lanthanide complex has strong anti-tumor activity in vitro.
The complex might have anti-tumor cooperation action.
研究镧系元素的生物化学、无机和有机抗肿瘤药物的协同作用。
用Ln(NO3)·6H2O、邻菲罗啉（Phen）和5-氟尿嘧啶（5-Fu）合成了一系列稀土配合物。采用改进的MTT法、SRB法测定其抗肿瘤活性。
通过元素分析、摩尔电导率、红外光谱、热重分析和13C核磁共振光谱对配合物Ln(Phen)2(5-Fu)3(NO3)2（Ln = Y、La、Ce、Sm、Gd、Dy、Er；Phen = 1,10-邻菲罗啉；5-Fu = 氟尿嘧啶）的化学式进行了表征。初步生物学活性研究表明，稀土配合物在体外具有较强的抗肿瘤活性。
该配合物可能具有抗肿瘤协同作用。
