Department of Chemistry, Faculty of Pharmacy, Medical University, 2 Dunav St., Sofia 1000, Bulgaria.
J Trace Elem Med Biol. 2010 Jan;24(1):7-13. doi: 10.1016/j.jtemb.2009.06.004. Epub 2009 Aug 8.
New La(III) and Dy(III) complexes of deprotonated 4-hydroxy-3[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one (Acenocoumarol) were synthesized and characterized using FT-IR, FT-Raman, (1)H NMR spectra, and elemental analyses. The ligand and its lanthanide(III) complexes were tested for their cytotoxic/cytostatic activity against two tumor cell lines and peritoneal mouse macrophages. The La(III) and Dy(III) complexes exhibit good activity against melanoma B16 and fibrosarcoma L929 and they are stronger inhibitors of tumor cell proliferation compared to the ligand without influencing normal cell viability and NO release by mouse peritoneal macrophages.
合成并利用傅里叶变换红外光谱（FT-IR）、傅里叶变换拉曼光谱（FT-Raman）、（1）H NMR 谱和元素分析对去质子的 4-羟基-3[1-(4-硝基苯基)-3-氧代丁基]-2H-1-苯并吡喃-2-酮（乙酰水杨酸）的镧（III）和镝（III）配合物进行了表征。对配体及其镧系元素（III）配合物进行了细胞毒性/细胞抑制活性测试，以评估其对两种肿瘤细胞系和腹腔小鼠巨噬细胞的作用。镧（III）和镝（III）配合物对黑色素瘤 B16 和纤维肉瘤 L929 具有良好的活性，并且与不影响正常细胞活力和由小鼠腹腔巨噬细胞释放的 NO 的配体相比，它们是更强的肿瘤细胞增殖抑制剂。
