[Current approaches to studying the pathogenesis of endotoxicosis in acute exogenous poisoning].

The clinical and laboratory picture of endotoxicosis (ET) was studied in 356 patients with different forms of acute poisoning, which established the fundamental similarity of the laboratory manifestations of ET at both stages of poisoning (toxicogenic and somatogenic complicated by respiratory disorders and toxicohypoxic encephalopathy) as manifested by changes in direct ET markers (the blood level of medium-weight molecules, the leukocytic index of intoxication, etc.) and in other homeostatic parameters (hemorrheological, immune, and others). Multivariance statistical analysis established the association of the development of ET with the blood levels of exogenous toxicants and its greatest implication in the development of hemorrheological disorders. The findings allow one to consider the early diagnosis and stepwise correction of ET to be the basis of a pathogenetic approach to treating acute poisoning.