Savilov P N
Anesteziol Reanimatol. 2005 Nov-Dec(6):59-62.
The study was undertaken to examine nitrogen metabolism in gastrointenstinal tract tissues in endogenous ammonia intoxication caused by liver resection (LR) and the impact of three-day hyperbaric oxygenation (HBO) on the metabolism. The albino rat samples of arterial (aortic) and venous (portal) blood and the tissues of the stomach, duodenum, and large bowel were the subject of this investigation. HBO was made thrice at 3 ata as a 50-min session within the first three days after LR (15-20% of the mass of the organ). The levels of ammonia, glutamine, and urea were measured. HBO prevents postoperative arterial hyperammonemia, the gastrointestinal accumulation of ammonia, by reducing its accumulation in the portal blood. HBO stimulates the development of LR-caused portal hyperglutaminemia and the decrease of GIT tissue uptake of "arterial" glutamine and regulates the influence of an operation on the levels of this metabolite in GIT tissues. HBO elevates the content of urea in the arterial and portal blood, without affecting the LR-induced change in its GIT tissue concentration. Hyperbaric oxygen regulates adaptive GIT tissue nitrogen metabolic reactions caused in response to liver resection.
本研究旨在探讨肝切除（LR）所致内源性氨中毒时胃肠道组织中的氮代谢，以及为期三天的高压氧治疗（HBO）对该代谢的影响。本研究的对象为白化大鼠的动脉（主动脉）和静脉（门静脉）血样本以及胃、十二指肠和大肠组织。在LR（切除器官质量的15 - 20%）后的头三天内，以3个绝对大气压进行三次HBO治疗，每次治疗50分钟。测量了氨、谷氨酰胺和尿素的水平。HBO通过减少门静脉血中氨的蓄积，预防术后动脉血高氨血症及胃肠道氨的蓄积。HBO刺激LR所致门静脉高谷氨酰胺血症的发展，降低胃肠道组织对“动脉”谷氨酰胺的摄取，并调节手术对胃肠道组织中这种代谢物水平的影响。HBO提高动脉血和门静脉血中尿素的含量，但不影响LR引起的胃肠道组织中尿素浓度的变化。高压氧调节胃肠道组织因肝切除而引起的适应性氮代谢反应。
