Schlienger J L, Imler M
Hepatogastroenterology. 1980 Dec;27(6):441-7.
In order to specify the role of peripheral muscular tissue in ammonia metabolism, we studied, in rats, the variations of ammonia and glutamine levels in arterial and femoral venous blood after hepatectomy and abdominal evisceration with nephrectomy. In non-fasting rats this operation was immediately followed by an important hyperammonemia which was due to ammonia muscular release; glutamine blood levels increased only slightly without any modification in their arterio-femoral venous differences. The hyperammonemia induced by hepatectomy-evisceration was greatly reduced in animals which had been fasting for 48 hours but was not modified by a 72hrs preoperative sucrose feeding. These nutritional conditions did not change the blood glutamine variations which were first related to the abdominal evisceration. Indeed, in abdominal eviscerated rats without hepatectomy there was an important hyperglutaminemia with only a slight increase in blood ammonia. These results indicate that in rat 1) the liver plays an important part in skeletal muscle ammonia metabolism, 2) this metabolism is related to food ingestion, 3) the gastrointestinal tissue intervenes in glutamine metabolism.
为了明确外周肌肉组织在氨代谢中的作用，我们对大鼠进行了研究，观察肝切除及腹部脏器摘除并肾切除后动脉血和股静脉血中氨和谷氨酰胺水平的变化。在非禁食大鼠中，此手术之后随即出现显著的高氨血症，这是由于肌肉释放氨所致；谷氨酰胺血水平仅略有升高，其动脉-股静脉差异未发生任何改变。肝切除-脏器摘除诱导的高氨血症在禁食48小时的动物中大幅降低，但术前72小时给予蔗糖喂养对此并无影响。这些营养状况并未改变最初与腹部脏器摘除相关的血谷氨酰胺变化。实际上，在未进行肝切除的腹部脏器摘除大鼠中，存在显著的高谷氨酰胺血症，血氨仅略有升高。这些结果表明，在大鼠中：1）肝脏在骨骼肌氨代谢中起重要作用；2）这种代谢与食物摄入有关；3）胃肠道组织参与谷氨酰胺代谢。
